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Tbio
IL37
Interleukin-37

Protein Summary
Description
Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263326
  • ENSP00000263326
  • ENSG00000125571
  • ENST00000311328
  • ENSP00000309883
  • ENST00000349806
  • ENSP00000263328
  • ENST00000352179
  • ENSP00000263327
  • ENST00000353225
  • ENSP00000309208

Symbol
  • FIL1Z
  • IL1F7
  • IL1H4
  • IL1RP1
  • FIL1
  • FIL1Z
  • IL-1H
  • IL-37
  • IL1F7
  • IL1H4
  • IL-1F7
  • IL-1H4
  • IL1RP1
  • IL-1RP1
  • FIL1(ZETA)
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
gene perturbation
0.53
biological term
0.5
cell type or tissue
0.47
phenotype
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.85   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 284   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 285.85   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 284   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-1 beta measurement
1
4
4
98.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
interleukin-1 beta measurement
4
98.2
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-1 family signaling
Reactome
Interleukin-18 signaling
Reactome
Interleukin-37 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-1 family signaling
Interleukin-18 signaling
Interleukin-37 signaling
Gene Ontology Terms (16)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (77)
1 – 10 of 77
FADD
Tbio
Novelty: 0.00137968
p_int: 0.999723203
p_ni: 0.000276796
p_wrong: 1e-9
Score: 0.578
Data Source: BioPlex,STRINGDB
HES4
Tbio
Family: TF
Novelty: 0.05290912
p_int: 0.987897416
p_ni: 0.009555375
p_wrong: 0.002547209
Data Source: BioPlex
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.979958055
p_ni: 0.01932588
p_wrong: 0.000716065
Data Source: BioPlex
GPANK1
Tdark
Novelty: 0.20285376
p_int: 0.97835038
p_ni: 0.021022162
p_wrong: 0.000627458
Score: 0.199
Data Source: BioPlex,STRINGDB
ZSCAN12
Tdark
Family: TF
Novelty: 0.33578207
p_int: 0.968795095
p_ni: 0.030450684
p_wrong: 0.000754221
Score: 0.179
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.000863
p_int: 0.944090058
p_ni: 0.055908359
p_wrong: 0.000001583
Data Source: BioPlex
CCDC103
Tbio
Novelty: 0.07857649
p_int: 0.931644328
p_ni: 0.068355538
p_wrong: 1.35e-7
Data Source: BioPlex
BEX5
Tdark
Novelty: 0.2964824
p_int: 0.913156359
p_ni: 0.086836678
p_wrong: 0.000006963
Data Source: BioPlex
GSG1
Tdark
Novelty: 2.47475466
p_int: 0.892439433
p_ni: 0.107559301
p_wrong: 0.000001266
Score: 0.379
Data Source: BioPlex,STRINGDB
IL18BP
Tbio
Novelty: 0.00838895
Score: 0.986
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  285.85

PubMed score by year
PubTator Score  362.5

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer