Tbio GPRC5B G-protein coupled receptor family C group 5 member B

Protein Summary

Description

Unknown. This retinoic acid-inducible G-protein coupled receptor provide evidence for a possible interaction between retinoid and G-protein signaling pathways. This gene encodes a member of the type 3 G protein-coupled receptor family. Members of this superfamily are characterized by a signature 7-transmembrane domain motif. The encoded protein may modulate insulin secretion and increased protein expression is associated with type 2 diabetes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Uniprot Accession IDs

• Q9NZH0
• D2DFB0
• O75205
• Q8NBZ8

Gene Name

• GPRC5B

Ensembl ID

• ENST00000300571
• ENSP00000300571
• ENSG00000167191
• ENST00000535671
• ENSP00000442858
• ENST00000569479
• ENSP00000454727
• ENST00000569847
• ENSP00000457283

Symbol

• RAIG2
• RAIG2
• RAIG-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
biological process	0.81
gene perturbation	0.81
histone modification site profile	0.77
molecular function	0.73

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor Family C Group 5 Member B

DTO Classes

Protein / G-protein Coupled Receptor / Class C Metabotropic Glutamate/pheromone / G-protein Coupled Receptor Family C Group 5 Member B

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 289   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.61   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 289   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0