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Tbio
SPG21
Maspardin

Protein Summary
Description
May play a role as a negative regulatory factor in CD4-dependent T-cell activation. The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000204566
  • ENSP00000204566
  • ENSG00000090487
  • ENST00000416889
  • ENSP00000394846
  • ENST00000433215
  • ENSP00000404111

Symbol
  • ACP33
  • MAST
  • ACP33
  • GL010
  • ABHD21
  • BM-019
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.98
kinase perturbation
0.97
virus perturbation
0.92
histone modification site profile
0.84


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (77)
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.999999936
p_ni:  6.1e-8
p_wrong:  3e-9
Score:  0.319
Data Source:  BioPlex,STRINGDB
ARL8A
Tbio
Family:  Enzyme
Novelty:  0.12499089
p_int:  0.999999713
p_ni:  1.7e-7
p_wrong:  1.17e-7
Data Source:  BioPlex
XXYLT1
Tbio
Family:  Enzyme
Novelty:  0.16837376
p_int:  0.999889559
p_ni:  0.000008671
p_wrong:  0.00010177
Data Source:  BioPlex
AKIRIN2
Tbio
Novelty:  0.04603317
p_int:  0.999786635
p_ni:  0.000005738
p_wrong:  0.000207627
Score:  0.364
Data Source:  BioPlex,STRINGDB
ALDH16A1
Tdark
Family:  Enzyme
Novelty:  0.21880567
Score:  0.904
Data Source:  STRINGDB
SPG11
Tbio
Novelty:  0.00697875
Score:  0.748
Data Source:  STRINGDB
SPAST
Tbio
Novelty:  0.00303236
Score:  0.716
Data Source:  STRINGDB
NIPA1
Tbio
Novelty:  0.02398766
Score:  0.684
Data Source:  STRINGDB
ZFYVE26
Tbio
Novelty:  0.04897973
Score:  0.682
Data Source:  STRINGDB
AP5Z1
Tbio
Family:  TF
Novelty:  0.14368974
Score:  0.681
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (7)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
5
4
4
3.4
96.8
mean platelet volume
2
2
2
86.7
white matter hyperintensity measurement
2
2
1
5.7
31.3
platelet crit
1
1
1
24.3
pulse pressure measurement
1
1
1
12.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
4
3.4
96.8
mean platelet volume
2
86.7
white matter hyperintensity measurement
1
5.7
31.3
platelet crit
1
24.3
pulse pressure measurement
1
12.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SPG21, maspardin
453510
Macaque
SPG21, maspardin
712815
Mouse
MGI:106403
27965
Rat
RGD:1359141
300791
Dog
SPG21, maspardin
VGNC:46735
487599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SPG21, maspardin
Macaque
SPG21, maspardin
Mouse
Rat
Dog
SPG21, maspardin
Publication Statistics
PubMed Score 14.43
PubMed score by year
PubTator Score 61.49
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title