Protein Summary
May play a role as a negative regulatory factor in CD4-dependent T-cell activation. The protein encoded by this gene binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. Mutations in this gene are associated with autosomal recessive spastic paraplegia 21 (SPG21), also known as mast syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
- ENST00000204566
- ENSP00000204566
- ENSG00000090487
- ENST00000416889
- ENSP00000394846
- ENST00000433215
- ENSP00000404111
- ACP33
- MAST
- ACP33
- GL010
- ABHD21
- BM-019
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
transcription factor perturbation | 0.98 | ||
kinase perturbation | 0.97 | ||
virus perturbation | 0.92 | ||
histone modification site profile | 0.84 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.43 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 14.43 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (77)
ATPAF2
Family: Enzyme
Novelty: 0.04184643
p_int: 0.999999936
p_ni: 6.1e-8
p_wrong: 3e-9
Score: 0.319
Data Source: BioPlex,STRINGDB
ARL8A
Family: Enzyme
Novelty: 0.12499089
p_int: 0.999999713
p_ni: 1.7e-7
p_wrong: 1.17e-7
Data Source: BioPlex
XXYLT1
Family: Enzyme
Novelty: 0.16837376
p_int: 0.999889559
p_ni: 0.000008671
p_wrong: 0.00010177
Data Source: BioPlex
AKIRIN2
Novelty: 0.04603317
p_int: 0.999786635
p_ni: 0.000005738
p_wrong: 0.000207627
Score: 0.364
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (1)
KEGG (1)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | Endocytosis | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Endocytosis | ||||
Viral Interactions (0)
Gene Ontology Terms (7)
Functions (1)
Components (5)
Processes (1)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
platelet count | 5 | 4 | 4 | 3.4 | 96.8 | ||||
mean platelet volume | 2 | 2 | 2 | 86.7 | |||||
white matter hyperintensity measurement | 2 | 2 | 1 | 5.7 | 31.3 | ||||
platelet crit | 1 | 1 | 1 | 24.3 | |||||
pulse pressure measurement | 1 | 1 | 1 | 12.6 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
platelet count | 4 | 3.4 | 96.8 | ||||
mean platelet volume | 2 | 86.7 | |||||
white matter hyperintensity measurement | 1 | 5.7 | 31.3 | ||||
platelet crit | 1 | 24.3 | |||||
pulse pressure measurement | 1 | 12.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | SPG21, maspardin | 453510 | ||||||
Macaque | SPG21, maspardin | 712815 | ||||||
Mouse | MGI:106403 | 27965 | ||||||
Rat | RGD:1359141 | 300791 | ||||||
Dog | SPG21, maspardin | VGNC:46735 | 487599 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | SPG21, maspardin | |||||
Macaque | SPG21, maspardin | |||||
Mouse | ||||||
Rat | ||||||
Dog | SPG21, maspardin | |||||
Publication Statistics
PubMed Score 14.43
PubMed score by year
PubTator Score 61.49
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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