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Tbio
GPRC5D
G-protein coupled receptor family C group 5 member D

Protein Summary
Description
The protein encoded by this gene is a member of the G protein-coupled receptor family; however, the specific function of this gene has not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228887
  • ENSP00000228887
  • ENSG00000111291
  • ENST00000396333
  • ENSP00000379624
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.65
cell type or tissue
0.61
cell line
0.47
pathway
0.45
disease perturbation
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 191   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.46   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
PRR9
Tdark
Novelty:  0.09345601
Score:  0.624
Data Source:  STRINGDB
B4GALT4
Tbio
Family:  Enzyme
Novelty:  0.11226614
Score:  0.611
Data Source:  STRINGDB
GPR156
Tdark
Family:  GPCR
Novelty:  0.39183023
Score:  0.596
Data Source:  STRINGDB
SNHG28
Tdark
Novelty:  1.12069377
Score:  0.588
Data Source:  STRINGDB
VSIG8
Tdark
Novelty:  1.16023405
Score:  0.582
Data Source:  STRINGDB
GPR179
Tdark
Family:  GPCR
Novelty:  0.09278403
Score:  0.56
Data Source:  STRINGDB
VSTM4
Tdark
Novelty:  0.46711608
Score:  0.543
Data Source:  STRINGDB
SEC63
Tbio
Novelty:  0.00974614
Score:  0.534
Data Source:  STRINGDB
LRRC15
Tbio
Novelty:  0.03701624
Score:  0.527
Data Source:  STRINGDB
GPBAR1
Tchem
Family:  GPCR
Novelty:  0.00290465
Score:  0.474
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (34)
Find Similar Targets
Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Class C Metabotropic glutamate, pheromone
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
WikiPathways
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
WikiPathways
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Name
Explore in Pharos
Explore in Source
GPCRs, Class C Metabotropic glutamate, pheromone
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
Amplification and Expansion of Oncogenic Pathways as Metastatic Traits
PI3K-AKT-mTOR signaling pathway and therapeutic opportunities
Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
2
3
90.9
hematocrit
3
1
3
81.3
red blood cell density measurement
1
1
1
77.9
mean reticulocyte volume
1
1
1
70.8
1
1
0
1.1
62.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
90.9
hematocrit
3
81.3
red blood cell density measurement
1
77.9
mean reticulocyte volume
1
70.8
0
1.1
62.6
Find similar targets by:
IDG Resources
Genetic Construct
GPRC5D-Tango
image for GPRC5D-Tango
Details:
  • Vector:  addgene66385
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  FLAG
Data:
  • GPRC5D-Tango
Order Genetic Construct from:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 5 member D
VGNC:8601
473370
Macaque
G protein-coupled receptor class C group 5 member D
698898
Mouse
MGI:1935037
93746
Rat
RGD:1563887
500349
Dog
G protein-coupled receptor class C group 5 member D
VGNC:41451
486679
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein-coupled receptor class C group 5 member D
Macaque
G protein-coupled receptor class C group 5 member D
Mouse
Rat
Dog
G protein-coupled receptor class C group 5 member D
Publication Statistics
PubMed Score 14.46
PubMed score by year
PubTator Score 11.77
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title