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Tbio
SMARCAL1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1

Protein Summary
Description
ATP-dependent annealing helicase that binds selectively to fork DNA relative to ssDNA or dsDNA and catalyzes the rewinding of the stably unwound DNA. Rewinds single-stranded DNA bubbles that are stably bound by replication protein A (RPA). Acts throughout the genome to reanneal stably unwound DNA, performing the opposite reaction of many enzymes, such as helicases and polymerases, that unwind DNA. May play an important role in DNA damage response by acting at stalled replication forks. The protein encoded by this gene is a member of the SWI/SNF family of proteins. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein shows sequence similarity to the E. coli RNA polymerase-binding protein HepA. Mutations in this gene are a cause of Schimke immunoosseous dysplasia (SIOD), an autosomal recessive disorder with the diagnostic features of spondyloepiphys ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000357276
  • ENSP00000349823
  • ENSG00000138375
  • ENST00000358207
  • ENSP00000350940

Symbol
  • HARP
  • HARP
  • HHARP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.98
protein domain
0.85
histone modification site profile
0.81
transcription factor binding site profile
0.77
interacting protein
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.77   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 177   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.77   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 177   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
1
1
1
29.8
intelligence
1
1
0
5.6
25.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter integrity
1
29.8
intelligence
0
5.6
25.2
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
VGNC:10370
459930
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
695741
Mouse
MGI:1859183
54380
Rat
RGD:1306134
316477
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
VGNC:46533
478903
Species
Name
OMA
EggNOG
Inparanoid
Chimp
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
Macaque
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
Mouse
Rat
Dog
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (131)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Wnt signaling pathway
PathwayCommons: pid
ATR signaling pathway
Name
Explore in Pharos
Explore in Source
Wnt signaling pathway
ATR signaling pathway
Gene Ontology Terms (16)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (85)
1 – 10 of 85
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01401705
p_int: 0.999999835
p_ni: 1.65e-7
Data Source: BioPlex
DCAF7
Tbio
Novelty: 0.02609518
p_int: 0.99998286
p_ni: 0.000017113
p_wrong: 2.7e-8
Score: 0.204
Data Source: BioPlex,STRINGDB
AZIN2
Tbio
Family: Enzyme
Novelty: 0.00750311
p_int: 0.992649683
p_ni: 0.005942264
p_wrong: 0.001408052
Score: 0.318
Data Source: BioPlex,STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.999
Data Source: STRINGDB
RPA2
Tbio
Novelty: 0.00879115
Score: 0.999
Data Source: STRINGDB
RPA3
Tbio
Novelty: 0.00887858
Score: 0.994
Data Source: STRINGDB
PRIMPOL
Tbio
Family: Enzyme
Novelty: 0.01285041
Score: 0.994
Data Source: STRINGDB
STN1
Tbio
Novelty: 0.01309587
Score: 0.969
Data Source: STRINGDB
ATR
Tchem
Family: Kinase
Novelty: 0.00196978
Score: 0.944
Data Source: STRINGDB
TOPBP1
Tbio
Family: Enzyme
Novelty: 0.00735579
Score: 0.943
Data Source: STRINGDB
Publication Statistics
PubMed Score  85.77

PubMed score by year
PubTator Score  64.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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