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Tbio
GDE1
Glycerophosphodiester phosphodiesterase 1

Protein Summary
Description
Has glycerophosphoinositol phosphodiesterase activity. Hydrolyzes lysoglycerophospholipids to produce lysophosphatidic acid (LPA) and the corresponding amines. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353258
  • ENSP00000261386
  • ENSG00000006007

Symbol
  • MIR16
  • MIR16
  • 363E6.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.84
virus perturbation
0.79
microRNA
0.75
transcription factor binding site profile
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.86   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.86   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Glycerophospholipid catabolism (R-HSA-6814848)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid catabolism
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Glycerophospholipid catabolism
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (54)
1 – 10 of 54
REEP5
Tbio
Novelty: 0.00356586
p_int: 0.999999826
p_ni: 1.74e-7
Score: 0.193
Data Source: BioPlex,STRINGDB
CYB5B
Tbio
Novelty: 0.11412954
p_int: 0.999978897
p_ni: 0.000003035
p_wrong: 0.000018068
Data Source: BioPlex
SLC4A7
Tbio
Family: Transporter
Novelty: 0.01401859
p_int: 0.99997501
p_ni: 0.000024955
p_wrong: 3.5e-8
Score: 0.198
Data Source: BioPlex,STRINGDB
ADCY2
Tbio
Family: Enzyme
Novelty: 0.01612818
p_int: 0.999157181
p_ni: 0.000440346
p_wrong: 0.000402473
Score: 0.174
Data Source: BioPlex,STRINGDB
FAM84B
Tbio
Novelty: 0.11646844
p_int: 0.999130735
p_ni: 0.000020948
p_wrong: 0.000848317
Score: 0.325
Data Source: BioPlex,STRINGDB
APOA2
Tbio
Novelty: 0.00133324
p_int: 0.999043348
p_ni: 0.000873598
p_wrong: 0.000083054
Data Source: BioPlex
CXorf58
Tdark
Novelty: 4
p_int: 0.979665017
p_ni: 0.01583753
p_wrong: 0.004497453
Score: 0.622
Data Source: BioPlex,STRINGDB
ATL3
Tbio
Novelty: 0.07586934
p_int: 0.938477508
p_ni: 0.059571663
p_wrong: 0.00195083
Score: 0.21
Data Source: BioPlex,STRINGDB
CDK14
Tchem
Family: Kinase
Novelty: 0.02591455
p_int: 0.934136961
p_ni: 0.056269606
p_wrong: 0.009593433
Score: 0.311
Data Source: BioPlex,STRINGDB
DAZAP2
Tbio
Novelty: 0.03047855
p_int: 0.921578348
p_ni: 0.000022803
p_wrong: 0.078398849
Score: 0.199
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  8.86

PubMed score by year
PubTator Score  232.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer