Tbio TREM2 Triggering receptor expressed on myeloid cells 2

Protein Summary

Description

Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• Q9NZC2
• Q8N5H8
• Q8WYN6
• TREM-2

Gene Name

• TREM2

Ensembl ID

• ENST00000338469
• ENSP00000342651
• ENSG00000095970
• ENST00000373113
• ENSP00000362205
• ENST00000373122
• ENSP00000362214

Symbol

• PLOSL2
• TREM-2
• Trem2a
• Trem2b
• Trem2c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.87
gene perturbation	0.64
biological term	0.59
tissue sample	0.56
cell line	0.52

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 761.58   (req: < 5)

Gene RIFs: 315   (req: <= 3)

Antibodies: 521   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 761.58   (req: >= 5)

Gene RIFs: 315   (req: > 3)

Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0