You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TREM2
Triggering receptor expressed on myeloid cells 2

Protein Summary
Description
Forms a receptor signaling complex with TYROBP and triggers activation of the immune responses in macrophages and dendritic cells. May have a role in chronic inflammations and may stimulate production of constitutive rather than inflammatory chemokines and cytokines. This gene encodes a membrane protein that forms a receptor signaling complex with the TYRO protein tyrosine kinase binding protein. The encoded protein functions in immune response and may be involved in chronic inflammation by triggering the production of constitutive inflammatory cytokines. Defects in this gene are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338469
  • ENSP00000342651
  • ENSG00000095970
  • ENST00000373113
  • ENSP00000362205
  • ENST00000373122
  • ENSP00000362214

Symbol
  • PLOSL2
  • TREM-2
  • Trem2a
  • Trem2b
  • Trem2c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.87
gene perturbation
0.64
biological term
0.59
tissue sample
0.56
cell line
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.94   (req: < 5)
Gene RIFs: 142   (req: <= 3)
Antibodies: 521   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 352.94   (req: >= 5)
Gene RIFs: 142   (req: > 3)
Antibodies: 521   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
DAP12 interactions
Reactome
DAP12 signaling
Reactome
Developmental Biology
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
DAP12 interactions
DAP12 signaling
Developmental Biology
Gene Ontology Terms (27)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (136)
1 – 10 of 136
NUCB2
Tbio
Novelty: 0.00828843
p_int: 0.994823935
p_ni: 0.005176065
Data Source: BioPlex
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.0033925
p_int: 0.966649095
p_ni: 0.033350905
Data Source: BioPlex
TYROBP
Tbio
Family: Enzyme
Novelty: 0.00522854
Score: 0.997
Data Source: Reactome,STRINGDB
SYK
Tclin
Family: Kinase
Novelty: 0.00067612
Score: 0.96
Data Source: Reactome,STRINGDB
PLXNA1
Tbio
Novelty: 0.01144396
Score: 0.954
Data Source: Reactome,STRINGDB
SEMA6D
Tbio
Novelty: 0.02442925
Score: 0.937
Data Source: Reactome,STRINGDB
BTK
Tclin
Family: Kinase
Novelty: 0.000673
Score: 0.923
Data Source: STRINGDB
LCP2
Tbio
Novelty: 0.00631737
Score: 0.923
Data Source: STRINGDB
PLCG2
Tchem
Family: Enzyme
Novelty: 0.00370802
Score: 0.92
Data Source: STRINGDB
VAV3
Tbio
Novelty: 0.01366247
Score: 0.92
Data Source: STRINGDB
Publication Statistics
PubMed Score  352.94

PubMed score by year
PubTator Score  243.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: