Tbio FAM120A Constitutive coactivator of PPAR-gamma-like protein 1

Protein Summary

Description

May participate in mRNA transport in the cytoplasm (By similarity). Critical component of the oxidative stress-induced survival signaling. Activates src family kinases and acts as a scaffolding protein enabling src family kinases to phosphorylate and activate PI3-kinase. Binds RNA and promotes the secretion of IGF-II. May play a pivotal role in the progression of scirrhous-type gastric cancer by supporting cancer cell survival in environments with various oxidative stresses.

Uniprot Accession IDs

• Q9NZB2
• A6NGU0
• C4AMC6
• O60649
• Q14688
• Q4VXF4
• Q4VXF5
• Q4VXG2
• Q86V69
• Q96I21
• Q9NZB1

Gene Name

• FAM120A

Ensembl ID

• ENST00000277165
• ENSP00000277165
• ENSG00000048828
• ENST00000375389
• ENSP00000364538

Symbol

• C9orf10
• KIAA0183
• OSSA
• OSSA
• C9orf10
• HBVPTPAP

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	0.99
interacting protein	0.95
disease perturbation	0.87
PubMedID	0.71
transcription factor perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.81   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 118   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 17.81   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0