Tbio NLGN3 Neuroligin-3

Protein Summary

Description

Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• Q9NZ94
• B2RBK1
• D2X2H6
• D3DVV0
• D3DVV1
• Q86V51
• Q8NCD0
• Q9NZ95
• Q9NZ96
• Q9NZ97
• Q9P248

Gene Name

• NLGN3

Ensembl ID

• ENST00000358741
• ENSP00000351591
• ENSG00000196338
• ENST00000374051
• ENSP00000363163
• ENST00000536169
• ENSP00000445298

Symbol

• KIAA1480
• NL3
• HNL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.9
protein domain	0.73
tissue sample	0.73
cell type or tissue	0.67
cellular component	0.6

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.6   (req: < 5)

Gene RIFs: 34   (req: <= 3)

Antibodies: 259   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 151.6   (req: >= 5)

Gene RIFs: 34   (req: > 3)

Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0