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Tbio
NLGN3
Neuroligin-3

Protein Summary
Description
Cell surface protein involved in cell-cell-interactions via its interactions with neurexin family members. Plays a role in synapse function and synaptic signal transmission, and may mediate its effects by clustering other synaptic proteins. May promote the initial formation of synapses, but is not essential for this. May also play a role in glia-glia or glia-neuron interactions in the developing peripheral nervous system (By similarity). This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. Mutations in this gene may be associated with autism and Asperger syndrome. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358741
  • ENSP00000351591
  • ENSG00000196338
  • ENST00000374051
  • ENSP00000363163
  • ENST00000536169
  • ENSP00000445298

Symbol
  • KIAA1480
  • NL3
  • HNL3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.9
protein domain
0.73
tissue sample
0.73
cell type or tissue
0.67
cellular component
0.6


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.49   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 259   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 130.49   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 259   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 35
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (153)
NLGN4X
Tbio
Family:  Enzyme
Novelty:  0.01004489
p_int:  1
Score:  0.945
Data Source:  BioPlex,STRINGDB
NLGN4Y
Tbio
Family:  Enzyme
p_int:  1
Data Source:  BioPlex
NLGN1
Tbio
Family:  Enzyme
Novelty:  0.0097512
p_int:  0.999999999
p_wrong:  1e-9
Score:  0.938
Data Source:  BioPlex,STRINGDB
NLGN2
Tbio
Family:  Enzyme
Novelty:  0.01613168
p_int:  0.999999987
p_ni:  1.3e-8
Score:  0.923
Data Source:  BioPlex,STRINGDB
NLRX1
Tbio
Novelty:  0.00906898
p_int:  0.99985321
p_ni:  0.00014679
Score:  0.183
Data Source:  BioPlex,STRINGDB
TCAF2
Tbio
Family:  Enzyme
Novelty:  0.37070492
p_int:  0.997949346
p_ni:  0.002050641
p_wrong:  1.4e-8
Data Source:  BioPlex
UTP15
Tbio
Novelty:  0.08174586
p_int:  0.989983587
p_ni:  0.010016413
Score:  0.183
Data Source:  BioPlex,STRINGDB
RECQL4
Tbio
Family:  Enzyme
Novelty:  0.00576141
p_int:  0.953498664
p_ni:  0.046501336
p_wrong:  1e-9
Score:  0.196
Data Source:  BioPlex,STRINGDB
PIK3CB
Tchem
Family:  Kinase
Novelty:  0.00390277
p_int:  0.928914361
p_ni:  0.071078712
p_wrong:  0.000006927
Score:  0.206
Data Source:  BioPlex,STRINGDB
PIK3CA
Tclin
Family:  Kinase
Novelty:  0.00044273
p_int:  0.907674028
p_ni:  0.092305058
p_wrong:  0.000020914
Score:  0.326
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Neurexins and neuroligins (R-HSA-6794361)

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Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
Neuronal System
Protein-protein interactions at synapses
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (47)
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Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
2
3
94.6
reticulocyte count
2
1
2
86.6
testosterone measurement
1
1
1
12
2
1
0
1
10.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
94.6
reticulocyte count
2
86.6
testosterone measurement
1
12
0
1
10.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuroligin 3
VGNC:1217
473660
Mouse
MGI:2444609
245537
Rat
RGD:621119
171297
Dog
neuroligin 3
VGNC:43840
491947
Horse
neuroligin 3
VGNC:20761
100055823
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuroligin 3
Mouse
Rat
Dog
neuroligin 3
Horse
neuroligin 3
Publication Statistics
PubMed Score 130.49
PubMed score by year
PubTator Score 47.34
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title