You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
STMN3
Stathmin-3

Protein Summary
Description
Exhibits microtubule-destabilizing activity, which is antagonized by STAT3. This gene encodes a protein which is a member of the stathmin protein family. Members of this protein family form a complex with tubulins at a ratio of 2 tubulins for each stathmin protein. Microtubules require the ordered assembly of alpha- and beta-tubulins, and formation of a complex with stathmin disrupts microtubule formation and function. A pseudogene of this gene is located on chromosome 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000370053
  • ENSP00000359070
  • ENSG00000197457
  • ENST00000540534
  • ENSP00000439840

Symbol
  • SCLIP
  • SCLIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
PubMedID
0.78
tissue sample
0.68
gene perturbation
0.66
transcription factor binding site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 178   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.73   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 178   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (38)
1 – 10 of 38
STMN2
Tbio
Novelty:  0.00854367
p_int:  0.999979448
p_ni:  0.0000049
p_wrong:  0.000015652
Score:  0.218
Data Source:  BioPlex,STRINGDB
STMN1
Tbio
Novelty:  0.00117369
p_int:  0.999926868
p_ni:  0.00007303
p_wrong:  1.02e-7
Score:  0.168
Data Source:  BioPlex,STRINGDB
TEX37
Tdark
Novelty:  0.24100699
p_int:  0.999917012
p_ni:  0.000082967
p_wrong:  2.1e-8
Data Source:  BioPlex
CHAC2
Tbio
Family:  Enzyme
Novelty:  0.14706039
p_int:  0.993353535
p_ni:  0.006646465
Data Source:  BioPlex
ZER1
Tbio
Novelty:  0.02989698
p_int:  0.9433447
p_ni:  0.0566553
Data Source:  BioPlex
GABPB2
Tbio
Novelty:  0.52630478
Score:  0.678
Data Source:  STRINGDB
GABPB1
Tbio
Novelty:  0.01518726
Score:  0.678
Data Source:  STRINGDB
TUBB3
Tclin
Novelty:  0.00195963
Score:  0.554
Data Source:  STRINGDB
MAPK8
Tchem
Family:  Kinase
Novelty:  0.00055723
Score:  0.553
Data Source:  STRINGDB
ZGPAT
Tbio
Family:  Epigenetic
Novelty:  0.16971298
Score:  0.548
Data Source:  STRINGDB
Gene Ontology Terms (15)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
HGNC
GWAS Traits (54)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
8
4
0
1.4
96.6
8
3
0
1.4
94.9
glioblastoma multiforme
3
2
0
1.4
92.5
C-reactive protein measurement
3
3
3
90.6
forced expiratory volume
2
2
2
88.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.6
0
1.4
94.9
glioblastoma multiforme
0
1.4
92.5
C-reactive protein measurement
3
90.6
forced expiratory volume
2
88.9
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
stathmin 3
VGNC:6275
458412
Mouse
MGI:1277137
20262
Rat
RGD:3628
29246
Dog
stathmin 3
VGNC:46927
477288
Cow
stathmin 3
VGNC:35405
511110
Species
Name
OMA
EggNOG
Inparanoid
Chimp
stathmin 3
Mouse
Rat
Dog
stathmin 3
Cow
stathmin 3
Publication Statistics
PubMed Score 16.73
PubMed score by year
PubTator Score 10.50
PubTator score by year