You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FMN2
Formin-2

Protein Summary
Description
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganization (PubMed:22330775, PubMed:21730168). Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2 (PubMed:22330775, PubMed:21730168). Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport (By similarity). Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis (By similarity). Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest (PubMed:23375502). Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage (PubMed:2628748 ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000319653
  • ENSP00000318884
  • ENSG00000155816
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
1
cellular component
0.81
disease
0.75
biological process
0.72
phenotype
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 55.47   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
9
98.8
bone density
2
2
3
71.4
platelet crit
1
1
1
51.7
volumetric bone mineral density
1
1
1
50.6
mean corpuscular hemoglobin concentration
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
9
98.8
bone density
3
71.4
platelet crit
1
51.7
volumetric bone mineral density
1
50.6
mean corpuscular hemoglobin concentration
1
44.2
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1859252
54418
Dog
formin 2
VGNC:40913
490366
Horse
formin 2
VGNC:18071
100060203
Opossum
formin 2
100027801
Fruitfly
FBgn0000256
33611
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Dog
formin 2
Horse
formin 2
Opossum
formin 2
Fruitfly
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZ56-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (26)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
CEP19
Tbio
Novelty:  0.20749222
p_int:  0.999998186
p_ni:  0.000001814
Data Source:  BioPlex
IMP3
Tbio
Novelty:  0.42681287
p_int:  0.999940389
p_ni:  0.00005961
Data Source:  BioPlex
TGFBR2
Tchem
Family:  Kinase
Novelty:  0.00085381
p_int:  0.999778831
p_ni:  0.000219207
p_wrong:  0.000001962
Score:  0.233
Data Source:  BioPlex,STRINGDB
ACVR2B
Tchem
Family:  Kinase
Novelty:  0.00555742
p_int:  0.999388385
p_ni:  0.00061156
p_wrong:  5.5e-8
Data Source:  BioPlex
BOD1
Tbio
Novelty:  0.06404805
p_int:  0.999186465
p_ni:  0.000813535
p_wrong:  1e-9
Score:  0.228
Data Source:  BioPlex,STRINGDB
ALDH3B1
Tbio
Family:  Enzyme
Novelty:  0.03330389
p_int:  0.998572962
p_ni:  0.001427037
p_wrong:  1e-9
Score:  0.183
Data Source:  BioPlex,STRINGDB
SPATA5L1
Tdark
Family:  Enzyme
Novelty:  0.5393372
p_int:  0.997765327
p_ni:  0.00220728
p_wrong:  0.000027393
Score:  0.291
Data Source:  BioPlex,STRINGDB
GATD1
Tdark
Family:  Enzyme
Novelty:  0.40291197
p_int:  0.995361969
p_ni:  0.004636237
p_wrong:  0.000001794
Data Source:  BioPlex
CASP1
Tchem
Family:  Enzyme
Novelty:  0.00034643
p_int:  0.993082483
p_ni:  0.002241553
p_wrong:  0.004675964
Score:  0.336
Data Source:  BioPlex,STRINGDB
NRBP1
Tbio
Family:  Kinase
Novelty:  0.05902656
p_int:  0.98974261
p_ni:  0.009589418
p_wrong:  0.000667972
Data Source:  BioPlex
Publication Statistics
PubMed Score  55.47

PubMed score by year
PubTator Score  25.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: