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Tbio
GGA3
ADP-ribosylation factor-binding protein GGA3

Protein Summary
Description
Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF-dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (DXXLL) motif (PubMed:11301005). Mediates export of the GPCR receptor ADRA2B to the cell surface (PubMed:26811329). nvolved in BACE1 transport and sorting as well as regulation of BACE1 protein levels (PubMed:17553422, PubMed:15615712, PubMed:20484053). Regulates retrograde transport of BACE1 from endosomes to the trans-Golgi network via interaction through the VHS motif and dependent of BACE1 phosphorylation (PubMed:15615712). Modulates BACE1 protein levels intedepently of the interaction between VHS domain and DXXLL motif through recognition of ubiquitination (PubMed:20484053). Key player in a novel DXXLL-mediated endosomal sorting machinery to the recycling pathway that targets NTRK1 to the plasma membrane (By similarity ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000537686
  • ENSP00000438085
  • ENSG00000125447
  • ENST00000538886
  • ENSP00000446421
  • ENST00000578348
  • ENSP00000463288
  • ENST00000582717
  • ENSP00000462081
  • ENST00000649398
  • ENSP00000496890

Symbol
  • KIAA0154
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
virus perturbation
0.83
kinase perturbation
0.81
transcription factor binding site profile
0.79
cellular component
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.19   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.19   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
70.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
70.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 3
705751
Mouse
MGI:2384159
260302
Rat
RGD:1309553
360658
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 3
VGNC:41195
483310
Horse
golgi associated, gamma adaptin ear containing, ARF binding protein 3
VGNC:18322
100051989
Species
Name
OMA
EggNOG
Inparanoid
Macaque
golgi associated, gamma adaptin ear containing, ARF binding protein 3
Mouse
Rat
Dog
golgi associated, gamma adaptin ear containing, ARF binding protein 3
Horse
golgi associated, gamma adaptin ear containing, ARF binding protein 3
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZ52-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
MET receptor recycling
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Reactome
Rab regulation of trafficking
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
MET receptor recycling
Membrane Trafficking
Metabolism of proteins
Rab regulation of trafficking
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (137)
1 – 10 of 137
RABEP1
Tbio
Family: Enzyme
Novelty: 0.02318446
Score: 0.996
Data Source: Reactome,STRINGDB
IGF2R
Tchem
Novelty: 0.00138374
Score: 0.985
Data Source: STRINGDB
BACE1
Tchem
Family: Enzyme
Novelty: 0.00042175
Score: 0.983
Data Source: Reactome,STRINGDB
ARF1
Tchem
Family: Enzyme
Novelty: 0.00208554
Score: 0.983
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.981
Data Source: Reactome,STRINGDB
CRK
Tbio
Novelty: 0.00238512
Score: 0.965
Data Source: Reactome,STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.95
Data Source: STRINGDB
MET
Tclin
Family: Kinase
Novelty: 0.00037995
Score: 0.947
Data Source: Reactome,STRINGDB
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
Score: 0.94
Data Source: STRINGDB
RAB5A
Tbio
Family: Enzyme
Novelty: 0.00111347
Score: 0.937
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  45.19

PubMed score by year
PubTator Score  37.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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