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Tchem
CISD1
CDGSH iron-sulfur domain-containing protein 1

Protein Summary
Description
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333926
  • ENSP00000363041
  • ENSG00000122873

Symbol
  • C10orf70
  • ZCD1
  • ZCD1
  • MDS029
  • C10orf70
  • mitoNEET
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.84
transcription factor binding site profile
0.81
disease perturbation
0.74
cellular component
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.19   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.19   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 46
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (66)
WDR45
Tbio
Novelty:  0.0148072
p_int:  0.974765444
p_ni:  0.013392842
p_wrong:  0.011841714
Data Source:  BioPlex
CISD2
Tbio
Novelty:  0.01665752
p_int:  0.97337359
p_ni:  0.02662627
p_wrong:  1.39e-7
Data Source:  BioPlex
CHCHD2
Tbio
Novelty:  0.01615338
p_int:  0.867396882
p_ni:  0.132546813
p_wrong:  0.000056306
Score:  0.244
Data Source:  BioPlex,STRINGDB
PDLIM7
Tbio
Novelty:  0.00544518
p_int:  0.80246448
p_ni:  0.197528177
p_wrong:  0.000007342
Data Source:  BioPlex
CISD3
Tbio
Novelty:  0.10931756
Score:  0.945
Data Source:  STRINGDB
BCAP31
Tbio
Novelty:  0.01363316
Score:  0.883
Data Source:  STRINGDB
NDUFA2
Tclin
Family:  Enzyme
Novelty:  0.02698508
Score:  0.877
Data Source:  STRINGDB
STX12
Tbio
Novelty:  0.03836262
Score:  0.866
Data Source:  STRINGDB
P30536
Tchem
Novelty:  0.00082324
Score:  0.86
Data Source:  STRINGDB
B1AH88
Tchem
Novelty:  0.00082324
Score:  0.86
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Cell Differentiation - Index
Name
Explore in Pharos
Explore in Source
Adipogenesis
Adipogenesis
Adipogenesis
Adipogenesis
Cell Differentiation - Index
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
2
2
95.8
1
1
0
1.1
38.2
monocyte count
1
1
1
27.5
1
1
0
1.1
14.5
monocyte percentage of leukocytes
1
1
1
8.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mitochondrial DNA measurement
2
95.8
0
1.1
38.2
monocyte count
1
27.5
0
1.1
14.5
monocyte percentage of leukocytes
1
8.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CDGSH iron sulfur domain 1
VGNC:51970
748227
Macaque
CDGSH iron sulfur domain 1
701716
Mouse
MGI:1261855
52637
Rat
RGD:1309529
294362
Horse
CDGSH iron sulfur domain 1
100072162
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CDGSH iron sulfur domain 1
Macaque
CDGSH iron sulfur domain 1
Mouse
Rat
Horse
CDGSH iron sulfur domain 1
Publication Statistics
PubMed Score 121.19
PubMed score by year
PubTator Score 58.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title