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Tchem
CISD1
CDGSH iron-sulfur domain-containing protein 1

Protein Summary
Description
Plays a key role in regulating maximal capacity for electron transport and oxidative phosphorylation (By similarity). May be involved in Fe-S cluster shuttling and/or in redox reactions. This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333926
  • ENSP00000363041
  • ENSG00000122873

Symbol
  • C10orf70
  • ZCD1
  • ZCD1
  • MDS029
  • C10orf70
  • mitoNEET
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
kinase perturbation
0.84
transcription factor binding site profile
0.81
disease perturbation
0.74
cellular component
0.72


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.07   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.07   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Adipogenesis
WikiPathways
Cell Differentiation - Index
Name
Explore in Pharos
Explore in Source
Adipogenesis
Adipogenesis
Adipogenesis
Adipogenesis
Cell Differentiation - Index
Gene Ontology Terms (7)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (66)
1 – 10 of 66
WDR45
Tbio
Novelty: 0.0148072
p_int: 0.974765444
p_ni: 0.013392842
p_wrong: 0.011841714
Data Source: BioPlex
CISD2
Tbio
Novelty: 0.01665752
p_int: 0.97337359
p_ni: 0.02662627
p_wrong: 1.39e-7
Data Source: BioPlex
CHCHD2
Tbio
Novelty: 0.01615338
p_int: 0.867396882
p_ni: 0.132546813
p_wrong: 0.000056306
Score: 0.244
Data Source: BioPlex,STRINGDB
PDLIM7
Tbio
Novelty: 0.00544518
p_int: 0.80246448
p_ni: 0.197528177
p_wrong: 0.000007342
Data Source: BioPlex
CISD3
Tbio
Novelty: 0.10931756
Score: 0.945
Data Source: STRINGDB
BCAP31
Tbio
Novelty: 0.01363316
Score: 0.883
Data Source: STRINGDB
NDUFA2
Tclin
Family: Enzyme
Novelty: 0.02698508
Score: 0.877
Data Source: STRINGDB
STX12
Tbio
Novelty: 0.03836262
Score: 0.866
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00082324
Score: 0.86
Data Source: STRINGDB
TSPO
Tchem
Novelty: 0.00082324
Score: 0.86
Data Source: STRINGDB
Publication Statistics
PubMed Score  98.07

PubMed score by year
PubTator Score  58.82

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer