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Tbio
USE1
Vesicle transport protein USE1

Protein Summary
Description
SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000263897
  • ENSP00000263897
  • ENSG00000053501
  • ENST00000595101
  • ENSP00000472362
  • ENST00000596136
  • ENSP00000473239

Symbol
  • USE1L
  • D12
  • P31
  • SLT1
  • MDS032
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
disease perturbation
0.87
interacting protein
0.85
transcription factor binding site profile
0.84
transcription factor perturbation
0.84


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.35   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 205   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.35   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 205   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
3
6
96.7
mean corpuscular volume
1
3
3
96.7
HbA1c measurement
6
9
9
95.9
sex hormone-binding globulin measurement
6
2
8
95.9
testosterone measurement
5
3
5
95.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
6
96.7
mean corpuscular volume
3
96.7
HbA1c measurement
9
95.9
sex hormone-binding globulin measurement
8
95.9
testosterone measurement
5
95.6
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
unconventional SNARE in the ER 1
VGNC:8688
455822
Macaque
unconventional SNARE in the ER 1
718905
Mouse
MGI:1914273
67023
Rat
RGD:1306660
290627
Dog
unconventional SNARE in the ER 1
VGNC:48171
609734
Species
Name
OMA
EggNOG
Inparanoid
Chimp
unconventional SNARE in the ER 1
Macaque
unconventional SNARE in the ER 1
Mouse
Rat
Dog
unconventional SNARE in the ER 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZ43-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
COPI-dependent Golgi-to-ER retrograde traffic (R-HSA-6811434)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
COPI-dependent Golgi-to-ER retrograde traffic
Reactome
Golgi-to-ER retrograde transport
Reactome
Intra-Golgi and retrograde Golgi-to-ER traffic
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
COPI-dependent Golgi-to-ER retrograde traffic
Golgi-to-ER retrograde transport
Intra-Golgi and retrograde Golgi-to-ER traffic
Membrane Trafficking
Vesicle-mediated transport
Protein-Protein Interactions (148)
1 – 10 of 148
SCFD2
Tdark
Novelty:  0.38252131
p_int:  1
Score:  0.888
Data Source:  BioPlex,STRINGDB
STX18
Tbio
Novelty:  0.0259034
p_int:  0.999999999
p_ni:  1e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
RINT1
Tbio
Novelty:  0.04546291
p_int:  0.999999999
p_ni:  1e-9
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
SEC22B
Tbio
Novelty:  0.03035448
p_int:  0.9999977
p_ni:  0.0000023
Score:  0.995
Data Source:  BioPlex,Reactome,STRINGDB
NBAS
Tbio
Novelty:  0.01187862
p_int:  0.999996716
p_ni:  0.000003284
Score:  0.983
Data Source:  BioPlex,Reactome,STRINGDB
VAMP5
Tbio
Novelty:  0.09958312
p_int:  0.99995909
p_ni:  0.00004091
Score:  0.438
Data Source:  BioPlex,STRINGDB
STX12
Tbio
Novelty:  0.03836262
p_int:  0.999816112
p_ni:  0.000179248
p_wrong:  0.00000464
Score:  0.836
Data Source:  BioPlex,STRINGDB
TYW5
Tbio
Novelty:  0.1382439
p_int:  0.999708921
p_ni:  0.000291079
Score:  0.663
Data Source:  BioPlex,STRINGDB
VAMP4
Tbio
Novelty:  0.02949854
p_int:  0.999636322
p_ni:  0.000333709
p_wrong:  0.000029969
Score:  0.892
Data Source:  BioPlex,STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
p_int:  0.99521191
p_ni:  0.000656108
p_wrong:  0.004131983
Score:  0.228
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  109.35

PubMed score by year
PubTator Score  187.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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