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Tchem
PSENEN
Gamma-secretase subunit PEN-2

Protein Summary
Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222266
  • ENSP00000222266
  • ENSG00000205155
  • ENST00000587708
  • ENSP00000468411

Symbol
  • PEN2
  • PEN2
  • PEN-2
  • MDS033
  • ACNINV2
  • MSTP064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.87
disease perturbation
0.68
histone modification site profile
0.65
cellular component
0.64
tissue sample
0.64


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.64   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 792.64   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
64.9
thrombomodulin measurement
1
1
1
64
self reported educational attainment
1
1
1
46.1
mathematical ability
1
1
1
38.8
eosinophil percentage of leukocytes
1
1
1
37.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
64.9
thrombomodulin measurement
1
64
self reported educational attainment
1
46.1
mathematical ability
1
38.8
eosinophil percentage of leukocytes
1
37.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
presenilin enhancer gamma-secretase subunit
455962
Mouse
MGI:1913590
66340
Rat
RGD:1312037
292788
Dog
presenilin enhancer, gamma-secretase subunit
VGNC:53755
476479
Horse
presenilin enhancer, gamma-secretase subunit
VGNC:51066
100051536
Species
Name
OMA
EggNOG
Inparanoid
Chimp
presenilin enhancer gamma-secretase subunit
Mouse
Rat
Dog
presenilin enhancer, gamma-secretase subunit
Horse
presenilin enhancer, gamma-secretase subunit
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZ42-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (61)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Amyloid fiber formation
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Amyloid fiber formation
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (17)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (87)
1 – 10 of 87
APH1B
Tbio
Family:  Enzyme
Novelty:  0.03620802
Score:  0.999
Data Source:  Reactome,STRINGDB
PSEN1
Tchem
Family:  Enzyme
Novelty:  0.00024189
Score:  0.999
Data Source:  Reactome,STRINGDB
NCSTN
Tbio
Novelty:  0.00453935
Score:  0.999
Data Source:  Reactome,STRINGDB
PSEN2
Tchem
Family:  Enzyme
Novelty:  0.00112188
Score:  0.999
Data Source:  Reactome,STRINGDB
APH1A
Tbio
Family:  Enzyme
Novelty:  0.00794922
Score:  0.999
Data Source:  Reactome,STRINGDB
TMED10
Tbio
Novelty:  0.02742083
Score:  0.976
Data Source:  STRINGDB
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.967
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.935
Data Source:  STRINGDB
NOTCH2
Tchem
Novelty:  0.00195617
Score:  0.932
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.927
Data Source:  STRINGDB
Publication Statistics
PubMed Score  792.64

PubMed score by year
PubTator Score  177.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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