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Tchem
PSENEN
Gamma-secretase subunit PEN-2

Protein Summary
Description
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid-beta precursor protein) (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). The gamma-secretase complex plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins, and by regulating cytosolic CTNNB1 levels (Probable). PSENEN modulates both endoproteolysis of presenilin and gamma-secretase activity (PubMed:12522139, PubMed:12763021, PubMed:12740439, PubMed:12679784, PubMed:24941111). Presenilins, which are components of the gamma-secretase protein complex, are required for intramembranous processing of some type I transmembrane proteins, such as the Notch proteins and the beta-amyloid precursor protein. Signaling by Notch receptors mediates a wide range of developmental cell fates. Processi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222266
  • ENSP00000222266
  • ENSG00000205155
  • ENST00000587708
  • ENSP00000468411

Symbol
  • PEN2
  • PEN2
  • PEN-2
  • MDS033
  • ACNINV2
  • MSTP064
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
0.87
disease perturbation
0.68
histone modification site profile
0.65
cellular component
0.64
tissue sample
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.29   (req: < 5)
Gene RIFs: 55   (req: <= 3)
Antibodies: 243   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 650.29   (req: >= 5)
Gene RIFs: 55   (req: > 3)
Antibodies: 243   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (61)
Activated NOTCH1 Transmits Signal to the Nucleus (R-HSA-2122948)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activated NOTCH1 Transmits Signal to the Nucleus
Reactome
Amyloid fiber formation
Reactome
Axon guidance
Reactome
Cell death signalling via NRAGE, NRIF and NADE
Reactome
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Name
Explore in Pharos
Explore in Source
Activated NOTCH1 Transmits Signal to the Nucleus
Amyloid fiber formation
Axon guidance
Cell death signalling via NRAGE, NRIF and NADE
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Gene Ontology Terms (17)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HGNC
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (87)
1 – 10 of 87
APH1B
Tbio
Family: Enzyme
Novelty: 0.06372483
Score: 0.999
Data Source: Reactome,STRINGDB
PSEN1
Tchem
Family: Enzyme
Novelty: 0.00034716
Score: 0.999
Data Source: Reactome,STRINGDB
NCSTN
Tbio
Novelty: 0.00628726
Score: 0.999
Data Source: Reactome,STRINGDB
PSEN2
Tchem
Family: Enzyme
Novelty: 0.00153251
Score: 0.999
Data Source: Reactome,STRINGDB
APH1A
Tbio
Family: Enzyme
Novelty: 0.01327464
Score: 0.999
Data Source: Reactome,STRINGDB
TMED10
Tbio
Novelty: 0.0307377
Score: 0.976
Data Source: STRINGDB
NOTCH1
Tchem
Novelty: 0.00014278
Score: 0.967
Data Source: STRINGDB
DLL1
Tbio
Novelty: 0.00146023
Score: 0.935
Data Source: STRINGDB
NOTCH2
Tchem
Novelty: 0.0026339
Score: 0.932
Data Source: STRINGDB
NOTCH3
Tchem
Novelty: 0.00119412
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  650.29

PubMed score by year
PubTator Score  177.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer