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Tbio
PLA2G3
Group 3 secretory phospholipase A2

Protein Summary
Description
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Shows an 11-fold preference for phosphatidylglycerol over phosphatidylcholine (PC). Preferential cleavage: 1-palmitoyl-2-linoleoyl-phosphatidylethanolamine (PE) > 1-palmitoyl-2-linoleoyl-PC > 1-palmitoyl-2-arachidonoyl-PC > 1-palmitoyl-2-arachidonoyl-PE. Plays a role in ciliogenesis. This gene encodes a protein that belongs to the secreted phospholipase A2 family, whose members include the bee venom enzyme. The encoded enzyme functions in lipid metabolism and catalyzes the calcium-dependent hydrolysis of the sn-2 acyl bond of phospholipids to release arachidonic acid and lysophospholipids. This enzyme acts as a negative regulator of ciliogenesis, and may play a role in cancer development by stimulating tumor cell growth and angiogenesis. This gene is associated with oxidative stress, and polymorphisms in this gene are linked to risk for Alzheimer's disease. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215885
  • ENSP00000215885
  • ENSG00000100078

Symbol
  • SPLA2III
  • sPLA2-III
  • GIII-SPLA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.95
biological process
0.79
small molecule perturbation
0.65
microRNA
0.59
phenotype
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 166   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.02   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
1
3
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
3
86
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group III
VGNC:9924
470183
Mouse
MGI:2444945
237625
Rat
RGD:1305323
289733
Dog
phospholipase A2 group III
VGNC:44625
486361
Horse
phospholipase A2 group III
VGNC:21512
100058509
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phospholipase A2 group III
Mouse
Rat
Dog
phospholipase A2 group III
Horse
phospholipase A2 group III
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NZ20-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Acyl chain remodelling of PC (R-HSA-1482788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Acyl chain remodelling of PC
Reactome
Acyl chain remodelling of PE
Reactome
Acyl chain remodelling of PG
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Name
Explore in Pharos
Explore in Source
Acyl chain remodelling of PC
Acyl chain remodelling of PE
Acyl chain remodelling of PG
Glycerophospholipid biosynthesis
Metabolism
Gene Ontology Terms (21)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (79)
1 – 10 of 79
PCSK1N
Tbio
Novelty: 0.02656799
p_int: 0.977451911
p_ni: 0.002980932
p_wrong: 0.019567157
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.840549243
p_ni: 0.159450757
Data Source: BioPlex
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.788873292
p_ni: 0.211126708
Data Source: BioPlex
PLA2G2D
Tchem
Family: Enzyme
Novelty: 0.01212618
Score: 0.9
Data Source: STRINGDB
PLA2G15
Tbio
Family: Enzyme
Novelty: 0.01546393
Score: 0.897
Data Source: STRINGDB
PLA2G12A
Tbio
Family: Enzyme
Novelty: 0.08838195
Score: 0.807
Data Source: STRINGDB
PLA2G10
Tchem
Family: Enzyme
Novelty: 0.00289317
Score: 0.805
Data Source: STRINGDB
PLA2G7
Tchem
Family: Enzyme
Novelty: 0.00270949
Score: 0.789
Data Source: STRINGDB
PTGS2
Tclin
Family: Enzyme
Novelty: 0.00007089
Score: 0.774
Data Source: STRINGDB
PLD3
Tbio
Family: Enzyme
Novelty: 0.01610007
Score: 0.763
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.02

PubMed score by year
PubTator Score  10.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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