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Tbio
UBAP1
Ubiquitin-associated protein 1

Protein Summary
Description
Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Plays a role in the proteasomal degradation of ubiquitinated cell-surface proteins, such as EGFR and BST2. This gene is a member of the UBA domain family, whose members include proteins having connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin binding domain consisting of a compact three helix bundle. This particular protein originates from a gene locus in a refined region on chromosome 9 undergoing loss of heterozygosity in nasopharyngeal carcinoma (NPC). Taking into account its cytogenetic location, this UBA domain family member is being studies as a putative target for mutation in nasopharyngeal carcinomas. Multiple alternatively spliced transcript variants encoding different isoforms have ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297661
  • ENSP00000297661
  • ENSG00000165006
  • ENST00000359544
  • ENSP00000352541
  • ENST00000379186
  • ENSP00000368484
  • ENST00000625521
  • ENSP00000486574

Symbol
  • UAP
  • UBAP
  • NAG20
  • UBAP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.84
disease perturbation
0.74
transcription factor binding site profile
0.74
virus perturbation
0.72


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.99   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 180   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.99   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 180   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
VPS28
Tbio
Novelty:  0.02927315
p_int:  1
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
VPS37A
Tbio
Novelty:  0.09309134
p_int:  0.999999979
p_ni:  2e-9
p_wrong:  1.9e-8
Score:  0.998
Data Source:  BioPlex,Reactome,STRINGDB
VPS37B
Tbio
Novelty:  0.22081527
p_int:  0.999999439
p_ni:  5.61e-7
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
TSG101
Tbio
Novelty:  0.00211746
p_int:  0.999798431
p_ni:  0.000201569
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
MVB12A
Tbio
Novelty:  0.09794
Score:  0.978
Data Source:  STRINGDB
MVB12B
Tbio
Novelty:  0.15964868
Score:  0.974
Data Source:  STRINGDB
VPS37C
Tbio
Novelty:  0.24520685
Score:  0.965
Data Source:  Reactome,STRINGDB
VPS37D
Tdark
Novelty:  1.44882563
Score:  0.965
Data Source:  Reactome,STRINGDB
VPS36
Tbio
Novelty:  0.03382542
Score:  0.963
Data Source:  Reactome,STRINGDB
PTPN23
Tbio
Family:  Enzyme
Novelty:  0.03578001
Score:  0.962
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
Assembly Of The HIV Virion (R-HSA-175474)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly Of The HIV Virion
Reactome
Autophagy
Reactome
Budding and maturation of HIV virion
Reactome
Disease
Reactome
Endosomal Sorting Complex Required For Transport (ESCRT)
Name
Explore in Pharos
Explore in Source
Assembly Of The HIV Virion
Autophagy
Budding and maturation of HIV virion
Disease
Endosomal Sorting Complex Required For Transport (ESCRT)
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (11)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
79.8
testosterone measurement
5
2
5
78.9
neutrophil percentage of leukocytes
2
2
2
76.7
mean corpuscular hemoglobin concentration
1
1
1
75
monocyte percentage of leukocytes
1
1
1
74.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
79.8
testosterone measurement
5
78.9
neutrophil percentage of leukocytes
2
76.7
mean corpuscular hemoglobin concentration
1
75
monocyte percentage of leukocytes
1
74.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ubiquitin associated protein 1
701140
Mouse
MGI:2149543
67123
Rat
RGD:1305186
362502
Horse
ubiquitin associated protein 1
VGNC:24707
100053997
Cow
ubiquitin associated protein 1
VGNC:36571
517788
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ubiquitin associated protein 1
Mouse
Rat
Horse
ubiquitin associated protein 1
Cow
ubiquitin associated protein 1
Publication Statistics
PubMed Score 44.99
PubMed score by year
PubTator Score 17.52
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title