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Tchem
ERAP1
Endoplasmic reticulum aminopeptidase 1

Protein Summary
Description
Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney. The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296754
  • ENSP00000296754
  • ENSG00000164307
  • ENST00000443439
  • ENSP00000406304

Symbol
  • APPILS
  • ARTS1
  • KIAA0525
  • ALAP
  • A-LAP
  • ARTS1
  • ERAAP
  • APPILS
  • ARTS-1
  • ERAAP1
  • PILSAP
  • PILS-AP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.99
transcription factor perturbation
0.98
cellular component
0.81
biological term
0.76
histone modification site profile
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.32   (req: < 5)
Gene RIFs: 138   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 308.32   (req: >= 5)
Gene RIFs: 138   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 27
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (27)
SID56373872
Rendered image for SID56373872
CHEMBL4101200
Rendered image for CHEMBL4101200
compound 17 [PMID: 23916253]
Rendered image for compound 17 [PMID: 23916253]
CHEMBL3355101
Rendered image for CHEMBL3355101
CHEMBL3355104
Rendered image for CHEMBL3355104
CHEMBL3416733
Rendered image for CHEMBL3416733
CHEMBL4097268
Rendered image for CHEMBL4097268
CHEMBL4095882
Rendered image for CHEMBL4095882
CHEMBL4099107
Rendered image for CHEMBL4099107
Protein-Protein Interactions (163)
P01889
Tbio
Novelty:  0.00790207
p_int:  0.995685228
p_ni:  0.004314772
Score:  0.676
Data Source:  BioPlex,STRINGDB
OPALIN
Tdark
Novelty:  0.08221612
p_int:  0.994133731
p_ni:  0.005866269
Data Source:  BioPlex
MUL1
Tbio
Family:  Enzyme
Novelty:  0.00841786
p_int:  0.991029756
p_ni:  0.008970244
Score:  0.173
Data Source:  BioPlex,STRINGDB
TMEM87A
Tdark
Novelty:  0.33614983
p_int:  0.988596582
p_ni:  0.011403187
p_wrong:  2.31e-7
Score:  0.161
Data Source:  BioPlex,STRINGDB
APOL2
Tbio
Novelty:  0.06076255
p_int:  0.966760407
p_ni:  0.03323856
p_wrong:  0.000001033
Score:  0.199
Data Source:  BioPlex,STRINGDB
DHCR24
Tchem
Family:  Enzyme
Novelty:  0.00480473
p_int:  0.951371802
p_ni:  0.048628198
Score:  0.21
Data Source:  BioPlex,STRINGDB
SCGB1D4
Tdark
Novelty:  0.15597658
p_int:  0.932676516
p_ni:  0.067323483
p_wrong:  1e-9
Data Source:  BioPlex
SLC16A10
Tbio
Family:  Transporter
Novelty:  0.02363735
p_int:  0.927846849
p_ni:  0.029398028
p_wrong:  0.042755123
Data Source:  BioPlex
INS
Tbio
Novelty:  0.00000499
p_int:  0.906928059
p_ni:  0.093071941
Score:  0.315
Data Source:  BioPlex,STRINGDB
ROMO1
Tbio
Novelty:  0.01909602
p_int:  0.825742232
p_ni:  0.174257768
Score:  0.622
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Class I MHC mediated antigen processing & presentation
Immune System
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
HGNC
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
5
0
1.2
96.9
4
4
0
1.1
90.1
2
2
0
1.1
77.8
neutrophil count
2
2
2
73.4
1
1
0
1.5
66.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
96.9
0
1.1
90.1
0
1.1
77.8
neutrophil count
2
73.4
0
1.5
66.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum aminopeptidase 1
VGNC:3978
471835
Macaque
endoplasmic reticulum aminopeptidase 1
699996
Mouse
MGI:1933403
80898
Rat
RGD:708542
80897
Dog
endoplasmic reticulum aminopeptidase 1
VGNC:40433
488898
Species
Name
OMA
EggNOG
Inparanoid
Chimp
endoplasmic reticulum aminopeptidase 1
Macaque
endoplasmic reticulum aminopeptidase 1
Mouse
Rat
Dog
endoplasmic reticulum aminopeptidase 1
Publication Statistics
PubMed Score 308.32
PubMed score by year
PubTator Score 185.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title