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Tbio
TECR
Very-long-chain enoyl-CoA reductase

Protein Summary
Description
Catalyzes the last of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme reduces the trans-2,3-enoyl-CoA fatty acid intermediate to an acyl-CoA that can be further elongated by entering a new cycle of elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. This gene encodes a multi-pass membrane protein that resides in the endoplasmic reticulum, and belongs to the steroid 5-alpha reductase family. The elongation of microsomal long and very long chain fatty acid consists of 4 sequential reactions. This protein catalyzes the final step, reducing trans-2,3-enoyl-CoA to saturated acyl-CoA. Alternatively spliced transcript variants have been found for this gene.[provided ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215567
  • ENSP00000215567
  • ENSG00000099797

Symbol
  • GPSN2
  • SC2
  • SC2
  • TER
  • GPSN2
  • MRT14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
transcription factor perturbation
0.97
tissue
0.71
cellular component
0.68
transcription factor binding site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.26   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 890.26   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
1
2
65.9
mean corpuscular hemoglobin concentration
1
1
1
65.3
reticulocyte measurement
3
1
3
64
urolithiasis
1
1
0
1.1
63.4
risk-taking behaviour
2
2
2
54.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
2
65.9
mean corpuscular hemoglobin concentration
1
65.3
reticulocyte measurement
3
64
urolithiasis
0
1.1
63.4
risk-taking behaviour
2
54.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
trans-2,3-enoyl-CoA reductase
VGNC:1869
455786
Macaque
trans-2,3-enoyl-CoA reductase
718928
Mouse
MGI:1915408
106529
Rat
RGD:620376
191576
Dog
trans-2,3-enoyl-CoA reductase
VGNC:47234
476687
Species
Name
OMA
EggNOG
Inparanoid
Chimp
trans-2,3-enoyl-CoA reductase
Macaque
trans-2,3-enoyl-CoA reductase
Mouse
Rat
Dog
trans-2,3-enoyl-CoA reductase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NZ01-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Synthesis of very long-chain fatty acyl-CoAs
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Synthesis of very long-chain fatty acyl-CoAs
Protein-Protein Interactions (88)
1 – 10 of 88
HACD2
Tbio
Family:  Enzyme
Novelty:  0.16943742
Score:  0.992
Data Source:  STRINGDB
HACD1
Tbio
Family:  Enzyme
Novelty:  0.02323512
Score:  0.973
Data Source:  STRINGDB
HSD17B12
Tbio
Family:  Enzyme
Novelty:  0.02200219
Score:  0.965
Data Source:  STRINGDB
HACD3
Tbio
Family:  Enzyme
Novelty:  0.07336359
Score:  0.963
Data Source:  STRINGDB
HACD4
Tbio
Family:  Enzyme
Novelty:  0.20315286
Score:  0.962
Data Source:  STRINGDB
ERMAP
Tbio
Novelty:  0.04270359
Score:  0.909
Data Source:  STRINGDB
PIK3C2B
Tchem
Family:  Kinase
Novelty:  0.02410654
Score:  0.907
Data Source:  STRINGDB
ACOT2
Tbio
Family:  Enzyme
Novelty:  0.03086222
Score:  0.902
Data Source:  STRINGDB
ACOT4
Tbio
Family:  Enzyme
Novelty:  0.13441184
Score:  0.902
Data Source:  STRINGDB
ACOT1
Tbio
Family:  Enzyme
Novelty:  0.01211801
Score:  0.902
Data Source:  STRINGDB
Publication Statistics
PubMed Score  890.26

PubMed score by year
PubTator Score  129.34

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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