You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
SIGLEC8
Sialic acid-binding Ig-like lectin 8

Protein Classes
Protein Summary
Description
Putative adhesion molecule that mediates sialic-acid dependent binding to red blood cells (PubMed:10856141, PubMed:10625619). Preferentially binds to alpha-2,3-linked sialic acid. Also binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface (PubMed:10625619). Recognizes simultaneously epitopes having a terminal N-acetylneuraminic acid (sialic acid) and an underlying 6-O-sulfated galactose. Preferentially binds to Gal-6-sulfated sialyl-Lewis X glycan epitopes (PubMed:27357658). Sialic acid-binding immunoglobulin (Ig)-like lectins, or SIGLECs (e.g., CD33 (MIM 159590)), are a family of type 1 transmembrane proteins each having a unique expression pattern, mostly in hemopoietic cells. SIGLEC8 is a member of the CD33-like subgroup of SIGLECs, which are localized to 19q13.3-q13.4 and have 2 conserved cytoplasmic tyrosine-based motifs: an immunoreceptor tyrosine-based inhibitory motif, or ITIM (see MI ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000321424
  • ENSP00000321077
  • ENSG00000105366
  • ENST00000340550
  • ENSP00000339448

Symbol
  • SAF2
  • SAF2
  • SIGLEC-8
  • SIGLEC8L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
protein domain
0.85
tissue sample
0.62
small molecule perturbation
0.55
cell type or tissue
0.54


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.53   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 299   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.53   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 299   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
58.2
lymphocyte percentage of leukocytes
1
1
1
33.1
neutrophil percentage of leukocytes
1
1
1
10.2
1
1
0
1.8
2.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
58.2
lymphocyte percentage of leukocytes
1
33.1
neutrophil percentage of leukocytes
1
10.2
0
1.8
2.3
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 8
VGNC:13310
107966154
Species
Name
OMA
EggNOG
Inparanoid
Chimp
sialic acid binding Ig like lectin 8
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYZ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Immune System
Reactome
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Immune System
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (15)
1 – 10 of 15
IL5
Tclin
Novelty:  0.0001684
Score:  0.723
Data Source:  STRINGDB
CCR3
Tchem
Family:  GPCR
Novelty:  0.00197059
Score:  0.563
Data Source:  STRINGDB
CD300A
Tbio
Novelty:  0.01745189
Score:  0.539
Data Source:  STRINGDB
SIGLEC15
Tbio
Novelty:  0.04928596
Score:  0.526
Data Source:  STRINGDB
IL5RA
Tclin
Novelty:  0.01418963
Score:  0.52
Data Source:  STRINGDB
ST3GAL3
Tbio
Family:  Enzyme
Novelty:  0.01592595
Score:  0.512
Data Source:  STRINGDB
SLAMF1
Tbio
Novelty:  0.00112892
Score:  0.504
Data Source:  STRINGDB
EPX
Tchem
Family:  Enzyme
Novelty:  0.00339273
Score:  0.479
Data Source:  STRINGDB
IL33
Tbio
Novelty:  0.00072064
Score:  0.457
Data Source:  STRINGDB
TMEM145
Tdark
Novelty:  2.30428448
Score:  0.455
Data Source:  STRINGDB
Publication Statistics
PubMed Score  73.53

PubMed score by year
PubTator Score  47.18

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer