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Tbio
GTSE1
G2 and S phase-expressed protein 1

Protein Summary
Description
May be involved in p53-induced cell cycle arrest in G2/M phase by interfering with microtubule rearrangements that are required to enter mitosis. Overexpression delays G2/M phase progression. The protein encoded by this gene is only expressed in the S and G2 phases of the cell cycle, where it colocalizes with cytoplasmic tubulin and microtubules. In response to DNA damage, the encoded protein accumulates in the nucleus and binds the tumor suppressor protein p53, shuttling it out of the nucleus and repressing its ability to induce apoptosis. [provided by RefSeq, Jul 2008]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
transcription factor perturbation
0.96
histone modification site profile
0.86
protein complex
0.82
co-expressed gene
0.69


Related Tools
GENEVA
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.99   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 247   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.99   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 247   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G2 and S-phase expressed 1
VGNC:6154
458984
Macaque
G2 and S-phase expressed 1
714207
Mouse
MGI:1352755
29870
Rat
RGD:1563164
300126
Dog
G2 and S-phase expressed 1
VGNC:41559
608855
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G2 and S-phase expressed 1
Macaque
G2 and S-phase expressed 1
Mouse
Rat
Dog
G2 and S-phase expressed 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYZ3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (9)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Reactome
G2/M Checkpoints
Reactome
G2/M Transition
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
G2/M Checkpoints
G2/M Transition
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (229)
1 – 10 of 229
GAST
Tbio
Novelty: 0.00011795
p_int: 0.999999573
p_ni: 3.7e-8
p_wrong: 3.9e-7
Score: 0.67
Data Source: BioPlex,STRINGDB
ACAD11
Tbio
Family: Enzyme
Novelty: 0.22908145
p_int: 0.9998929
p_ni: 0.0001071
Data Source: BioPlex
CAV3
Tbio
Novelty: 0.00190092
p_int: 0.999832601
p_ni: 0.000167399
Score: 0.185
Data Source: BioPlex,STRINGDB
STAMBPL1
Tbio
Family: Enzyme
Novelty: 0.08532786
p_int: 0.999829871
p_ni: 0.000170129
Score: 0.377
Data Source: BioPlex,STRINGDB
XAGE3
Tdark
Novelty: 0.1418603
p_int: 0.999498938
p_ni: 0.000496412
p_wrong: 0.000004651
Score: 0.311
Data Source: BioPlex,STRINGDB
PPP2R3A
Tbio
Family: Enzyme
Novelty: 0.0350873
p_int: 0.998529391
p_ni: 0.001470503
p_wrong: 1.07e-7
Data Source: BioPlex
STAMBP
Tbio
Novelty: 0.01543821
p_int: 0.998469892
p_ni: 0.001529641
p_wrong: 4.66e-7
Score: 0.189
Data Source: BioPlex,STRINGDB
PICALM
Tbio
Novelty: 0.00800832
p_int: 0.995942244
p_ni: 0.004057755
Score: 0.604
Data Source: BioPlex,STRINGDB
DDB2
Tbio
Novelty: 0.00648809
p_int: 0.993445642
p_ni: 0.006554358
Score: 0.263
Data Source: BioPlex,STRINGDB
IL17RA
Tclin
Novelty: 0.00416706
p_int: 0.990222544
p_ni: 0.009777456
Data Source: BioPlex
Publication Statistics
PubMed Score  25.99

PubMed score by year
PubTator Score  10.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer