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Tbio
SLC25A37
Mitoferrin-1

Protein Summary
Description
Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme (By similarity). SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000290075
  • ENSP00000290075
  • ENSG00000147454
  • ENST00000519973
  • ENSP00000429200

Symbol
  • MFRN
  • MSCP
  • MSC
  • MFRN
  • MSCP
  • HT015
  • MFRN1
  • PRO1278
  • PRO1584
  • PRO2217
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.92
transcription factor perturbation
0.91
kinase perturbation
0.81
transcription factor binding site profile
0.78
cellular component
0.62


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.95   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 72.95   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (18)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
2
3
96
mean corpuscular hemoglobin concentration
5
3
5
93.9
red blood cell distribution width
4
3
5
92.5
sex hormone-binding globulin measurement
3
1
3
90.9
body mass index
1
1
1
74.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
3
96
mean corpuscular hemoglobin concentration
5
93.9
red blood cell distribution width
5
92.5
sex hormone-binding globulin measurement
3
90.9
body mass index
1
74.8
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 37
VGNC:14588
464058
Mouse
MGI:1914962
67712
Rat
RGD:1359361
306000
Dog
solute carrier family 25 member 37
VGNC:54360
486115
Horse
solute carrier family 25 member 37
VGNC:23110
100054026
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 37
Mouse
Rat
Dog
solute carrier family 25 member 37
Horse
solute carrier family 25 member 37
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYZ2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Mitochondrial iron-sulfur cluster biogenesis
Name
Explore in Pharos
Explore in Source
Metabolism
Mitochondrial iron-sulfur cluster biogenesis
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (73)
1 – 10 of 73
ABCB10
Tbio
Family: Transporter
Novelty: 0.00351852
Score: 0.952
Data Source: STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
Score: 0.878
Data Source: STRINGDB
FXN
Tbio
Novelty: 0.00084064
Score: 0.875
Data Source: STRINGDB
ABCB7
Tbio
Family: Transporter
Novelty: 0.00985796
Score: 0.864
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.75
Data Source: STRINGDB
ACO1
Tbio
Family: Enzyme
Novelty: 0.00194023
Score: 0.745
Data Source: STRINGDB
ISCU
Tbio
Novelty: 0.0043097
Score: 0.737
Data Source: STRINGDB
SLC11A2
Tchem
Family: Transporter
Novelty: 0.00189409
Score: 0.73
Data Source: STRINGDB
IREB2
Tbio
Novelty: 0.00300491
Score: 0.719
Data Source: STRINGDB
ZHX2
Tbio
Family: TF
Novelty: 0.01370086
Score: 0.719
Data Source: STRINGDB
Publication Statistics
PubMed Score  72.95

PubMed score by year
PubTator Score  17.92

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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