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Tbio
FASTKD2
FAST kinase domain-containing protein 2, mitochondrial

Protein Summary
Description
Plays an important role in assembly of the mitochondrial large ribosomal subunit (PubMed:25683715). As a component of a functional protein-RNA module, consisting of RCC1L, NGRN, RPUSD3, RPUSD4, TRUB2, FASTKD2 and 16S mitochondrial ribosomal RNA (16S mt-rRNA), controls 16S mt-rRNA abundance and is required for intra-mitochondrial translation (PubMed:27667664). This gene encodes a protein that is localized in the mitochondrial inner compartment and that may play a role in mitochondrial apoptosis. Nonsense mutations have been reported to result in cytochrome c oxidase deficiency. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236980
  • ENSP00000236980
  • ENSG00000118246
  • ENST00000402774
  • ENSP00000385990
  • ENST00000403094
  • ENSP00000384929

Symbol
  • KIAA0971
  • KIAA0971
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.92
histone modification site profile
0.83
transcription factor perturbation
0.8
tissue sample
0.74
transcription factor binding site profile
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.55   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
episodic memory
1
1
1
51.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
episodic memory
1
51.8
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAST kinase domains 2
VGNC:430
470625
Macaque
FAST kinase domains 2
709702
Mouse
MGI:1922869
75619
Rat
RGD:1307883
301463
Dog
FAST kinase domains 2
VGNC:40739
478884
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAST kinase domains 2
Macaque
FAST kinase domains 2
Mouse
Rat
Dog
FAST kinase domains 2
Gene Ontology Terms (11)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (87)
1 – 10 of 87
APIP
Tbio
Family: Enzyme
Novelty: 0.04661109
p_int: 0.999946943
p_ni: 0.000053057
Score: 0.198
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.99584007
p_ni: 0.00415993
Data Source: BioPlex
HNRNPA1
Tchem
Novelty: 0.0020871
p_int: 0.992389397
p_ni: 0.007610603
Score: 0.653
Data Source: BioPlex,STRINGDB
TRUB2
Tdark
Family: Enzyme
Novelty: 0.4130414
p_int: 0.990886094
p_ni: 0.009113906
Score: 0.914
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.989857457
p_ni: 0.010142543
Score: 0.546
Data Source: BioPlex,STRINGDB
YARS2
Tbio
Family: Enzyme
Novelty: 0.00522139
p_int: 0.978633507
p_ni: 0.021366493
Score: 0.833
Data Source: BioPlex,STRINGDB
MRPL30
Tdark
Novelty: 1.03623556
p_int: 0.966123846
p_ni: 0.033876154
Data Source: BioPlex
RBM47
Tbio
Novelty: 0.04787234
p_int: 0.96434524
p_ni: 0.03565476
Data Source: BioPlex
TNFRSF10C
Tbio
Novelty: 0.0088942
p_int: 0.959340728
p_ni: 0.040659272
Data Source: BioPlex
ZNF324B
Tdark
Family: TF
Novelty: 1.89922228
p_int: 0.959308738
p_ni: 0.040691262
Score: 0.313
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  9.55

PubMed score by year
PubTator Score  7.77

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer