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Tchem
PLK2
Serine/threonine-protein kinase PLK2

Protein Summary
Description
Tumor suppressor serine/threonine-protein kinase involved in synaptic plasticity, centriole duplication and G1/S phase transition. Polo-like kinases act by binding and phosphorylating proteins are that already phosphorylated on a specific motif recognized by the POLO box domains. Phosphorylates CENPJ, NPM1, RAPGEF2, RASGRF1, SNCA, SIPA1L1 and SYNGAP1. Plays a key role in synaptic plasticity and memory by regulating the Ras and Rap protein signaling: required for overactivity-dependent spine remodeling by phosphorylating the Ras activator RASGRF1 and the Rap inhibitor SIPA1L1 leading to their degradation by the proteasome. Conversely, phosphorylates the Rap activator RAPGEF2 and the Ras inhibitor SYNGAP1, promoting their activity. Also regulates synaptic plasticity independently of kinase activity, via its interaction with NSF that disrupts the interaction between NSF and the GRIA2 subunit of AMPARs, leading to a rapid rundown of AMPAR-mediated current that occludes long term depression ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274289
  • ENSP00000274289
  • ENSG00000145632

Symbol
  • SNK
  • SNK
  • hSNK
  • hPlk2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
hub protein
0.96
molecular function
0.96
PubMedID
0.94
biological process
0.93


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.79   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 142.79   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
53.3
self reported educational attainment
1
1
1
13.1
mathematical ability
1
1
1
1.8
intelligence
1
1
0
5.6
0.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
53.3
self reported educational attainment
1
13.1
mathematical ability
1
1.8
intelligence
0
5.6
0.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 2
VGNC:7102
461861
Macaque
polo like kinase 2
708835
Mouse
MGI:1099790
20620
Rat
RGD:620760
83722
Dog
polo like kinase 2
VGNC:44696
478063
Species
Name
OMA
EggNOG
Inparanoid
Chimp
polo like kinase 2
Macaque
polo like kinase 2
Mouse
Rat
Dog
polo like kinase 2
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYY3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (10)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
RNA Polymerase II Transcription
Reactome
TP53 Regulates Transcription of Cell Cycle Genes
Reactome
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
RNA Polymerase II Transcription
TP53 Regulates Transcription of Cell Cycle Genes
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Protein-Protein Interactions (180)
1 – 10 of 180
ANKRD44
Tdark
Family:  Enzyme
Novelty:  0.38360979
p_int:  0.999820724
p_ni:  0.00017916
p_wrong:  1.16e-7
Score:  0.492
Data Source:  BioPlex,STRINGDB
SUGP1
Tbio
Novelty:  0.00434166
p_int:  0.988713436
p_ni:  0.01128656
p_wrong:  4e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
SERPINB7
Tbio
Novelty:  0.01685387
p_int:  0.982626695
p_ni:  0.017373019
p_wrong:  2.86e-7
Score:  0.199
Data Source:  BioPlex,STRINGDB
SERPINA1
Tbio
Novelty:  0.00014098
p_int:  0.97974043
p_ni:  0.020175873
p_wrong:  0.000083697
Score:  0.208
Data Source:  BioPlex,STRINGDB
RABL6
Tbio
Family:  Enzyme
Novelty:  0.11501478
p_int:  0.96373865
p_ni:  0.036261347
p_wrong:  3e-9
Score:  0.223
Data Source:  BioPlex,STRINGDB
SDR9C7
Tbio
Family:  Enzyme
Novelty:  0.01618496
p_int:  0.948533421
p_ni:  0.051457149
p_wrong:  0.00000943
Score:  0.183
Data Source:  BioPlex,STRINGDB
ALAD
Tbio
Family:  Enzyme
Novelty:  0.00092757
p_int:  0.926009379
p_ni:  0.001247069
p_wrong:  0.072743551
Score:  0.188
Data Source:  BioPlex,STRINGDB
RNASE7
Tbio
Family:  Enzyme
Novelty:  0.01866347
p_int:  0.887882753
p_ni:  0.112117206
p_wrong:  4e-8
Data Source:  BioPlex
IGKC
Tdark
p_int:  0.881917956
p_ni:  0.118082043
p_wrong:  1e-9
Data Source:  BioPlex
CPA4
Tchem
Family:  Enzyme
Novelty:  0.01439845
p_int:  0.876299013
p_ni:  0.123700986
Score:  0.159
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  142.79

PubMed score by year
PubTator Score  131.83

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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