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Tbio
IL20
Interleukin-20

Protein Classes
Protein Summary
Description
Proinflammatory and angiogenic cytokine that may be involved in epidermal function and psoriasis. Angiogenic and proliferative activities are antagonized by IL10. May act through STAT3. The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367096
  • ENSP00000356063
  • ENSG00000162891
  • ENST00000367098
  • ENSP00000356065
  • ENST00000391930
  • ENSP00000375796

Symbol
  • ZCYTO10
  • IL-20
  • IL10D
  • ZCYTO10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
biological process
0.67
biological term
0.64
cell line
0.6
pathway
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: < 5)
Gene RIFs: 57   (req: <= 3)
Antibodies: 421   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: >= 5)
Gene RIFs: 57   (req: > 3)
Antibodies: 421   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
1
1
0
1.1
97.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Oral ulcer
0
1.1
97.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interleukin-20 family signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interleukin-20 family signaling
Signaling by Interleukins
Protein-Protein Interactions (64)
1 – 10 of 64
EMB
Tbio
Novelty: 0.00135577
p_int: 0.999459694
p_ni: 0.000536659
p_wrong: 0.000003646
Data Source: BioPlex
PPM1A
Tchem
Family: Enzyme
Novelty: 0.01464968
p_int: 0.998006335
p_ni: 0.001924359
p_wrong: 0.000069306
Data Source: BioPlex
LRP2
Tbio
Novelty: 0.00143258
p_int: 0.970296414
p_ni: 0.029703586
Data Source: BioPlex
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
p_int: 0.957540123
p_ni: 0.041782606
p_wrong: 0.00067727
Data Source: BioPlex
GFER
Tchem
Family: Enzyme
Novelty: 0.00338563
p_int: 0.944074155
p_ni: 0.055924884
p_wrong: 9.62e-7
Data Source: BioPlex
RTN4RL2
Tbio
Novelty: 0.05919593
p_int: 0.881585663
p_ni: 0.002716177
p_wrong: 0.11569816
Data Source: BioPlex
MICA
Tbio
Novelty: 0.03965901
p_int: 0.821711824
p_ni: 0.178277334
p_wrong: 0.000010841
Data Source: BioPlex
CADM4
Tbio
Novelty: 0.05034541
p_int: 0.786085162
p_ni: 0.113812132
p_wrong: 0.100102706
Data Source: BioPlex
GNG5
Tbio
Novelty: 0.1525101
p_int: 0.752823372
p_ni: 0.247142417
p_wrong: 0.000034211
Data Source: BioPlex
IL20RA
Tbio
Novelty: 0.02416816
Score: 0.994
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  0.23

PubMed score by year
PubTator Score  86.08

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer