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Tchem
TAS2R8
Taste receptor type 2 member 8

Protein Summary
Description
Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5. This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240615
  • ENSP00000240615
  • ENSG00000121314
  • ENST00000572823
  • ENSP00000461158
  • ENSG00000272712
  • ENST00000610444
  • ENSP00000484163
  • ENSG00000277316

Symbol
  • T2R8
  • TRB5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.79
cell line
0.55
tissue
0.47
cell type or tissue
0.41
pathway
0.38


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.11   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 36   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.11   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 36   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 72
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
isoprenaline
Rendered image for isoprenaline
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
6.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
6.5
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 8
738901
Horse
taste 2 receptor member 8
VGNC:23884
100063267
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 8
Horse
taste 2 receptor member 8
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYW2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Protein-Protein Interactions (232)
1 – 10 of 232
SERPINB8
Tbio
Novelty:  0.03308357
p_int:  0.778101106
p_ni:  0.22116975
p_wrong:  0.000729144
Score:  0.39
Data Source:  BioPlex,STRINGDB
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.974
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.954
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.939
Data Source:  STRINGDB
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.937
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.934
Data Source:  STRINGDB
TAS2R16
Tchem
Family:  GPCR
Novelty:  0.03181719
Score:  0.92
Data Source:  STRINGDB
SSTR3
Tclin
Family:  GPCR
Novelty:  0.00899073
Score:  0.916
Data Source:  STRINGDB
TAS2R5
Tchem
Family:  GPCR
Novelty:  0.08512891
Score:  0.915
Data Source:  STRINGDB
TAS2R60
Tchem
Family:  GPCR
Novelty:  0.95447184
Score:  0.914
Data Source:  STRINGDB
Publication Statistics
PubMed Score  5.11

PubMed score by year
PubTator Score  3.35

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer