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Tchem
TAS2R9
Taste receptor type 2 member 9

Protein Summary
Description
Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5 (By similarity). This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240691
  • ENSP00000240691
  • ENSG00000121381
  • ENST00000573524
  • ENSP00000460247
  • ENSG00000273086
  • ENST00000616297
  • ENSP00000480069
  • ENSG00000273713

Symbol
  • T2R9
  • TRB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.59
cell type or tissue
0.58
cell line
0.52
tissue
0.51
metabolite
0.45


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 94   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.45   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 94   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (231)
GNAT3
Tbio
Novelty:  0.00702357
Score:  0.975
Data Source:  STRINGDB
TAS1R3
Tbio
Family:  GPCR
Novelty:  0.00370936
Score:  0.967
Data Source:  STRINGDB
TAS1R2
Tbio
Family:  GPCR
Novelty:  0.00568766
Score:  0.964
Data Source:  STRINGDB
TAS1R1
Tbio
Family:  GPCR
Novelty:  0.00913004
Score:  0.958
Data Source:  STRINGDB
LPAR5
Tchem
Family:  GPCR
Novelty:  0.01883439
Score:  0.932
Data Source:  STRINGDB
MCHR2
Tchem
Family:  GPCR
Novelty:  0.01191922
Score:  0.926
Data Source:  STRINGDB
TAS2R4
Tchem
Family:  GPCR
Novelty:  0.02938385
Score:  0.923
Data Source:  STRINGDB
TAS2R16
Tchem
Family:  GPCR
Novelty:  0.03181719
Score:  0.922
Data Source:  STRINGDB
TAS2R38
Tchem
Family:  GPCR
Novelty:  0.004625
Score:  0.921
Data Source:  STRINGDB
CASR
Tclin
Family:  GPCR
Novelty:  0.00061316
Score:  0.919
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Class C/3 (Metabotropic glutamate/pheromone receptors) (R-HSA-420499)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class C/3 (Metabotropic glutamate/pheromone receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Class C/3 (Metabotropic glutamate/pheromone receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Signal Transduction
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
56.3
blood protein measurement
1
1
1
56.3
blood protein measurement
1
1
1
56.3
1
1
1
7.8
1
1
1
7.8
Items per page:
1 – 5 of 6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
56.3
blood protein measurement
1
56.3
blood protein measurement
1
56.3
1
7.8
1
7.8
IDG Resources
Items per page:
10
1 – 10 of 20
Genetic Construct
pcDNA3.1-GGamma13-GFP2
image for pcDNA3.1-GGamma13-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma9-GFP2
image for pcDNA3.1-GGamma9-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma8-GFP2
image for pcDNA3.1-GGamma8-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-GGamma1-GFP2
image for pcDNA3.1-GGamma1-GFP2
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta3
image for pcDNA3.1-Beta3
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA3.1-Beta1
image for pcDNA3.1-Beta1
Details:
  • Vector type:  cDNA
  • Vector backbone:  pcDNA3.1(+)
  • Promoter:  CMV
  • Tag:  not applicable
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Genetic Construct
pcDNA5/FRT/TO-GAlpha13-RLuc8
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Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha12-RLuc8
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Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha15-RLuc8
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Details:
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Genetic Construct
pcDNA5/FRT/TO-GAlpha11-RLuc8
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Details:
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Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 9
738958
Horse
taste 2 receptor member 9
VGNC:23885
100065228
Species
Name
OMA
EggNOG
Inparanoid
Chimp
taste 2 receptor member 9
Horse
taste 2 receptor member 9
Publication Statistics
PubMed Score 3.45
PubMed score by year
PubTator Score 2.69
PubTator score by year
Patents
Patents by year
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Related Publications
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PMID
Year
Title