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Tbio
RRN3
RNA polymerase I-specific transcription initiation factor RRN3

Protein Classes
Protein Summary
Description
Required for efficient transcription initiation by RNA polymerase I. Required for the formation of the competent preinitiation complex (PIC). Dissociates from pol I as a consequence of transcription. In vitro, cannot activate transcription in a subsequent transcription reaction (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000198767
  • ENSP00000198767
  • ENSG00000085721
  • ENST00000327307
  • ENSP00000318484
  • ENST00000564131
  • ENSP00000454238
  • ENST00000616334
  • ENSP00000480743
  • ENSG00000278494
  • ENST00000632541
  • ENSP00000488651
  • ENST00000634151
  • ENSP00000487821

Symbol
  • TIFIA
  • TIFIA
  • A-270G1.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.93
biological process
0.81
kinase
0.81
transcription factor binding site profile
0.81
protein complex
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.57   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 201   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 66.57   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 201   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (48)
Items per page:
1 – 5 of 48
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
6
4
9
95.6
triglyceride measurement
6
4
9
95.6
blood metabolite measurement
4
4
5
94.3
blood metabolite measurement
4
4
5
94.3
omega-6 polyunsaturated fatty acid measurement
2
2
3
94
Items per page:
1 – 5 of 48
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
9
95.6
triglyceride measurement
9
95.6
blood metabolite measurement
5
94.3
blood metabolite measurement
5
94.3
omega-6 polyunsaturated fatty acid measurement
3
94
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RRN3 homolog, RNA polymerase I transcription factor
VGNC:51603
741314
Macaque
RRN3 homolog, RNA polymerase I transcription factor
713500
Mouse
MGI:1925255
106298
Rat
RGD:1305001
304714
Dog
RRN3 homolog, RNA polymerase I transcription factor
479838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RRN3 homolog, RNA polymerase I transcription factor
Macaque
RRN3 homolog, RNA polymerase I transcription factor
Mouse
Rat
Dog
RRN3 homolog, RNA polymerase I transcription factor
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYV6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
RNA Polymerase I Promoter Clearance
Reactome
RNA Polymerase I Promoter Escape
Reactome
RNA Polymerase I Transcription
Reactome
RNA Polymerase I Transcription Initiation
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
RNA Polymerase I Promoter Clearance
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription
RNA Polymerase I Transcription Initiation
Protein-Protein Interactions (96)
1 – 10 of 96
TMEM108
Tbio
Novelty:  0.08687599
p_int:  0.999986885
p_ni:  0.000013076
p_wrong:  3.9e-8
Score:  0.248
Data Source:  BioPlex,STRINGDB
POLR1E
Tbio
Family:  Enzyme
Novelty:  0.09991103
p_int:  0.999957746
p_ni:  0.000042254
Score:  0.996
Data Source:  BioPlex,STRINGDB
CD3EAP
Tbio
Family:  Enzyme
Novelty:  0.04978272
p_int:  0.999861617
p_ni:  0.000090713
p_wrong:  0.00004767
Score:  0.966
Data Source:  BioPlex,STRINGDB
TWISTNB
Tdark
Family:  Enzyme
Novelty:  0.59160737
p_int:  0.999839024
p_ni:  0.000160972
p_wrong:  4e-9
Score:  0.998
Data Source:  BioPlex,STRINGDB
IL17RD
Tbio
Novelty:  0.02157815
p_int:  0.990437438
p_ni:  0.000899342
p_wrong:  0.00866322
Data Source:  BioPlex
POLR1A
Tchem
Family:  Enzyme
Novelty:  0.0485107
p_int:  0.981980746
p_ni:  0.018019254
Score:  0.996
Data Source:  BioPlex,STRINGDB
POLR1D
Tbio
Novelty:  0.01598347
p_int:  0.980808847
p_ni:  0.019191152
p_wrong:  2e-9
Score:  0.991
Data Source:  BioPlex,STRINGDB
POLR2L
Tbio
Family:  Enzyme
Novelty:  0.03847579
p_int:  0.96759835
p_ni:  0.03240035
p_wrong:  0.0000013
Score:  0.974
Data Source:  BioPlex,STRINGDB
POLR1B
Tbio
Family:  Enzyme
Novelty:  0.06955307
p_int:  0.966727736
p_ni:  0.033272264
Score:  0.997
Data Source:  BioPlex,STRINGDB
POLR1C
Tbio
Family:  Enzyme
Novelty:  0.04485332
p_int:  0.895496952
p_ni:  0.104503037
p_wrong:  1.1e-8
Score:  0.998
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  66.57

PubMed score by year
PubTator Score  32.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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