You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
UGGT1
UDP-glucose:glycoprotein glucosyltransferase 1

Protein Summary
Description
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000259253
  • ENSP00000259253
  • ENSG00000136731

Symbol
  • GT
  • UGCGL1
  • UGGT
  • UGT1
  • UGTR
  • UGT1
  • HUGT1
  • UGCGL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.88
transcription factor perturbation
0.88
disease perturbation
0.79
histone modification site profile
0.74
microRNA
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.92   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 121   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 63.92   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 121   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
2
2
57.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
57.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose glycoprotein glucosyltransferase 1
VGNC:2902
459600
Macaque
UDP-glucose glycoprotein glucosyltransferase 1
700462
Mouse
MGI:2443162
320011
Rat
RGD:619710
171129
Dog
UDP-glucose glycoprotein glucosyltransferase 1
VGNC:48118
476101
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose glycoprotein glucosyltransferase 1
Macaque
UDP-glucose glycoprotein glucosyltransferase 1
Mouse
Rat
Dog
UDP-glucose glycoprotein glucosyltransferase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYU2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Protein-Protein Interactions (84)
1 – 10 of 84
GXYLT1
Tdark
Family:  Enzyme
Novelty:  0.39064064
Score:  0.919
Data Source:  STRINGDB
GXYLT2
Tdark
Family:  Enzyme
Novelty:  0.43960075
Score:  0.909
Data Source:  STRINGDB
HS6ST1
Tbio
Family:  Enzyme
Novelty:  0.01352454
Score:  0.905
Data Source:  STRINGDB
CANX
Tbio
Novelty:  0.00087002
Score:  0.894
Data Source:  STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
Score:  0.876
Data Source:  STRINGDB
ALG6
Tbio
Family:  Enzyme
Novelty:  0.02610188
Score:  0.835
Data Source:  STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.823
Data Source:  STRINGDB
UGGT2
Tbio
Family:  Enzyme
Novelty:  0.20635638
Score:  0.81
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.775
Data Source:  STRINGDB
PDIA3
Tbio
Family:  Enzyme
Novelty:  0.00285939
Score:  0.772
Data Source:  STRINGDB
Publication Statistics
PubMed Score  63.92

PubMed score by year
PubTator Score  32.51

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: