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Tbio
UGGT2
UDP-glucose:glycoprotein glucosyltransferase 2

Protein Summary
Description
Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation (By similarity). UDP-glucose:glycoprotein glucosyltransferase (UGT) is a soluble protein of the endoplasmic reticulum (ER) that selectively reglucosylates unfolded glycoproteins, thus providing quality control for protein transport out of the ER.[supplied by OMIM, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376714
  • ENSP00000365904
  • ENSG00000102595
  • ENST00000376747
  • ENSP00000365938
  • ENST00000621375
  • ENSP00000482021

Symbol
  • UGCGL2
  • UGT2
  • UGT2
  • HUGT2
  • UGCGL2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
pathway
0.8
virus perturbation
0.72
cell line
0.69
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 125   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.1   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 125   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
1
1
31.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
urate measurement
1
31.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose glycoprotein glucosyltransferase 2
VGNC:7307
452628
Macaque
UDP-glucose glycoprotein glucosyltransferase 2
697784
Mouse
MGI:1913685
66435
Dog
UDP-glucose glycoprotein glucosyltransferase 2
VGNC:48119
485525
Horse
UDP-glucose glycoprotein glucosyltransferase 2
VGNC:24777
100059873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP-glucose glycoprotein glucosyltransferase 2
Macaque
UDP-glucose glycoprotein glucosyltransferase 2
Mouse
Dog
UDP-glucose glycoprotein glucosyltransferase 2
Horse
UDP-glucose glycoprotein glucosyltransferase 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYU1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Calnexin/calreticulin cycle
Reactome
ER Quality Control Compartment (ERQC)
Reactome
Metabolism of proteins
Reactome
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Calnexin/calreticulin cycle
ER Quality Control Compartment (ERQC)
Metabolism of proteins
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Protein-Protein Interactions (87)
1 – 10 of 87
BIRC6
Tbio
Novelty:  0.01187953
p_int:  0.987090988
p_ni:  0.012909012
Score:  0.268
Data Source:  BioPlex,STRINGDB
ITIH2
Tbio
Novelty:  0.04886358
p_int:  0.985919584
p_ni:  0.01302424
p_wrong:  0.001056176
Score:  0.269
Data Source:  BioPlex,STRINGDB
UGGT1
Tbio
Family:  Enzyme
Novelty:  0.0177085
Score:  0.81
Data Source:  STRINGDB
SLC35A2
Tbio
Family:  Transporter
Novelty:  0.00072521
Score:  0.763
Data Source:  STRINGDB
OS9
Tbio
Novelty:  0.01490339
Score:  0.739
Data Source:  STRINGDB
RNF17
Tbio
Family:  Epigenetic
Novelty:  0.09240471
Score:  0.715
Data Source:  STRINGDB
MOGS
Tbio
Family:  Enzyme
Novelty:  0.00527993
Score:  0.708
Data Source:  STRINGDB
ALG6
Tbio
Family:  Enzyme
Novelty:  0.02610188
Score:  0.706
Data Source:  STRINGDB
DNAJC3
Tbio
Novelty:  0.02129782
Score:  0.687
Data Source:  STRINGDB
CYB5D1
Tdark
Novelty:  1.31560651
Score:  0.687
Data Source:  STRINGDB
Publication Statistics
PubMed Score  3.10

PubMed score by year
PubTator Score  24.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer