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Tbio
WSB2
WD repeat and SOCS box-containing protein 2

Protein Summary
Description
May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000315436
  • ENSP00000319474
  • ENSG00000176871
  • ENST00000441406
  • ENSP00000409131
  • ENST00000544233
  • ENSP00000444431

Symbol
  • SBA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.95
kinase perturbation
0.93
virus perturbation
0.9
transcription factor perturbation
0.88
protein domain
0.85


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.34   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.34   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (191)
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.999999993
p_ni:  4e-9
p_wrong:  3e-9
Score:  0.746
Data Source:  BioPlex,STRINGDB
CLASRP
Tbio
Novelty:  0.00582947
p_int:  0.999981217
p_ni:  0.000018739
p_wrong:  4.3e-8
Score:  0.15
Data Source:  BioPlex,STRINGDB
ACIN1
Tbio
Novelty:  0.01675479
p_int:  0.999864976
p_ni:  0.000135024
Score:  0.461
Data Source:  BioPlex,STRINGDB
CCDC9
Tdark
Novelty:  0.73149492
p_int:  0.999839621
p_ni:  0.000160379
Score:  0.558
Data Source:  BioPlex,STRINGDB
RNF7
Tbio
Novelty:  0.02532658
p_int:  0.999570742
p_ni:  7.03e-7
p_wrong:  0.000428556
Score:  0.913
Data Source:  BioPlex,STRINGDB
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999395253
p_ni:  0.000604747
Score:  0.929
Data Source:  BioPlex,STRINGDB
ZC3H14
Tbio
Novelty:  0.07532778
p_int:  0.998318342
p_ni:  0.001681658
Score:  0.67
Data Source:  BioPlex,STRINGDB
ARIH2
Tbio
Family:  Enzyme
Novelty:  0.03455224
p_int:  0.992360729
p_ni:  0.007003932
p_wrong:  0.00063534
Score:  0.204
Data Source:  BioPlex,STRINGDB
NCBP3
Tbio
Novelty:  0.07581882
p_int:  0.991595495
p_ni:  0.008404505
Score:  0.663
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.981122373
p_ni:  0.018877627
Score:  0.182
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (4)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
3
1.1
86.4
comparative body size at age 10, self-reported
1
1
1
54.4
body mass index
2
2
2
45.2
insomnia measurement
1
1
0
1
38.2
depressive symptom measurement
2
2
1
5.6
37.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
86.4
comparative body size at age 10, self-reported
1
54.4
body mass index
2
45.2
insomnia measurement
0
1
38.2
depressive symptom measurement
1
5.6
37.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
WD repeat and SOCS box containing 2
VGNC:5649
741142
Macaque
WD repeat and SOCS box containing 2
695359
Mouse
MGI:2144041
59043
Rat
RGD:1359599
288692
Dog
WD repeat and SOCS box containing 2
VGNC:48436
477500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
WD repeat and SOCS box containing 2
Macaque
WD repeat and SOCS box containing 2
Mouse
Rat
Dog
WD repeat and SOCS box containing 2
Publication Statistics
PubMed Score 25.34
PubMed score by year
PubTator Score 8.33
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title