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Tbio
NKIRAS1
NF-kappa-B inhibitor-interacting Ras-like protein 1

Protein Summary
Description
Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to degradation. May act by blocking phosphorylation of NFKBIB and mediating cytoplasmic retention of p65/RELA NF-kappa-B subunit. It is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000388759
  • ENSP00000373411
  • ENSG00000197885
  • ENST00000416026
  • ENSP00000394214
  • ENST00000421515
  • ENSP00000392307
  • ENST00000425478
  • ENSP00000400385
  • ENST00000443659
  • ENSP00000393785
  • ENST00000614374
  • ENSP00000483749

Symbol
  • KBRAS1
  • KBRAS1
  • kappaB-Ras1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.91
molecular function
0.9
disease perturbation
0.83
transcription factor binding site profile
0.83
kinase perturbation
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 327   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 327   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
8
4
7
97
cognitive function measurement
1
1
1
88.7
self reported educational attainment
1
1
1
72.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
4
7
97
cognitive function measurement
1
88.7
self reported educational attainment
1
72.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor interacting Ras like 1
VGNC:13007
460227
Macaque
NFKB inhibitor interacting Ras like 1
699598
Mouse
MGI:1916971
69721
Rat
RGD:1308560
305751
Dog
NFKB inhibitor interacting Ras like 1
VGNC:43829
477047
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NFKB inhibitor interacting Ras like 1
Macaque
NFKB inhibitor interacting Ras like 1
Mouse
Rat
Dog
NFKB inhibitor interacting Ras like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYS0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Cytosolic sensors of pathogen-associated DNA
Reactome
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Cytosolic sensors of pathogen-associated DNA
DDX58/IFIH1-mediated induction of interferon-alpha/beta
Immune System
Innate Immune System
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (43)
1 – 10 of 43
CBLN4
Tbio
Novelty: 0.11296355
p_int: 0.999817627
p_ni: 0.000182371
p_wrong: 2e-9
Score: 0.206
Data Source: BioPlex,STRINGDB
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.997895064
p_ni: 0.000033979
p_wrong: 0.002070957
Score: 0.177
Data Source: BioPlex,STRINGDB
ARL4C
Tbio
Family: Enzyme
Novelty: 0.04764628
p_int: 0.993028519
p_ni: 0.006413745
p_wrong: 0.000557736
Score: 0.248
Data Source: BioPlex,STRINGDB
NAA30
Tbio
Family: Enzyme
Novelty: 0.04701961
p_int: 0.919923031
p_ni: 0.002466099
p_wrong: 0.07761087
Data Source: BioPlex
NFKBIB
Tbio
Novelty: 0.00517222
Score: 0.974
Data Source: STRINGDB
NFKBIA
Tchem
Novelty: 0.00022873
Score: 0.961
Data Source: STRINGDB
RELA
Tchem
Family: TF
Novelty: 0.0007137
Score: 0.926
Data Source: STRINGDB
NFKB2
Tchem
Family: TF
Novelty: 0.00366074
Score: 0.919
Data Source: STRINGDB
NFKB1
Tclin
Family: TF
Novelty: 0.00198195
Score: 0.918
Data Source: STRINGDB
TEX2
Tbio
Novelty: 0.07679544
Score: 0.721
Data Source: STRINGDB
Publication Statistics
PubMed Score  8.40

PubMed score by year
PubTator Score  5.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer