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Tbio
FAT2
Protocadherin Fat 2

Protein Summary
Description
Involved in the regulation of cell migration (PubMed:18534823). May be involved in mediating the organization of the parallel fibers of granule cells during cerebellar development (By similarity). This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261800
  • ENSP00000261800
  • ENSG00000086570

Symbol
  • CDHF8
  • KIAA0811
  • MEGF1
  • CDHF8
  • CDHR9
  • HFAT2
  • MEGF1
  • SCA45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.69
microRNA
0.63
tissue sample
0.62
cell type or tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 101   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (34)
PCP2
Tdark
Novelty:  0.05083955
Score:  0.718
Data Source:  STRINGDB
GABRA6
Tclin
Family:  IC
Novelty:  0.02894664
Score:  0.709
Data Source:  STRINGDB
RIMS1
Tbio
Novelty:  0.01126545
Score:  0.678
Data Source:  STRINGDB
KCNS1
Tclin
Family:  IC
Novelty:  0.06465987
Score:  0.667
Data Source:  STRINGDB
SLC36A1
Tchem
Family:  Transporter
Novelty:  0.03100896
Score:  0.651
Data Source:  STRINGDB
CBLN3
Tdark
Novelty:  0.21939076
Score:  0.624
Data Source:  STRINGDB
LAMC1
Tbio
Novelty:  0.01230796
Score:  0.624
Data Source:  STRINGDB
FJX1
Tbio
Novelty:  0.07957088
Score:  0.608
Data Source:  STRINGDB
NEUROD1
Tbio
Family:  TF
Novelty:  0.00188624
Score:  0.601
Data Source:  STRINGDB
ZNF750
Tbio
Novelty:  0.05236342
Score:  0.566
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (2)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
2
2
2
74.7
basophil count
2
2
2
66.6
body mass index
1
1
1
48.5
basophil percentage of granulocytes
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
basophil percentage of leukocytes
2
74.7
basophil count
2
66.6
body mass index
1
48.5
basophil percentage of granulocytes
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 2
VGNC:3997
462201
Macaque
FAT atypical cadherin 2
713698
Mouse
MGI:2685369
245827
Rat
RGD:620656
65048
Dog
FAT atypical cadherin 2
VGNC:40743
479323
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 2
Macaque
FAT atypical cadherin 2
Mouse
Rat
Dog
FAT atypical cadherin 2
Publication Statistics
PubMed Score 43.92
PubMed score by year
PubTator Score 19.03
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title