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Tbio
CELSR3
Cadherin EGF LAG seven-pass G-type receptor 3

Protein Summary
Description
Receptor that may have an important role in cell/cell signaling during nervous system formation. This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164024
  • ENSP00000164024
  • ENSG00000008300

Symbol
  • CDHF11
  • EGFL1
  • FMI1
  • KIAA0812
  • MEGF2
  • FMI1
  • EGFL1
  • HFMI1
  • MEGF2
  • ADGRC3
  • CDHF11
  • RESDA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.92
transcription factor perturbation
0.84
kinase perturbation
0.81
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.79   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.79   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.999996916
p_ni:  0.00000306
p_wrong:  2.4e-8
Data Source:  BioPlex
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.999841512
p_ni:  0.000158488
Score:  0.219
Data Source:  BioPlex,STRINGDB
PSG1
Tbio
Novelty:  0.0239046
p_int:  0.999683941
p_ni:  0.00029865
p_wrong:  0.00001741
Score:  0.539
Data Source:  BioPlex,STRINGDB
CD160
Tbio
Novelty:  0.01511748
p_int:  0.998471472
p_ni:  0.00152813
p_wrong:  3.98e-7
Data Source:  BioPlex
PSG9
Tbio
Novelty:  0.0426075
p_int:  0.9981523
p_ni:  0.0018477
Score:  0.666
Data Source:  BioPlex,STRINGDB
SIRT6
Tchem
Family:  Epigenetic
Novelty:  0.00155366
p_int:  0.997587919
p_ni:  0.00241208
Data Source:  BioPlex
PCDH20
Tbio
Novelty:  0.07862843
p_int:  0.995353433
p_ni:  0.004646566
p_wrong:  1e-9
Score:  0.551
Data Source:  BioPlex,STRINGDB
DKKL1
Tbio
Novelty:  0.00544618
p_int:  0.995194716
p_ni:  0.004805284
Score:  0.211
Data Source:  BioPlex,STRINGDB
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.995039848
p_ni:  0.004960036
p_wrong:  1.16e-7
Data Source:  BioPlex
TMED7
Tdark
Novelty:  0.31193294
p_int:  0.993133364
p_ni:  0.006753628
p_wrong:  0.000113008
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (20)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
2
5
5
89.5
self reported educational attainment
4
6
5
5.9
85.1
macrophage inflammatory protein 1b measurement
1
2
2
82.4
mathematical ability
2
3
3
81.7
chronotype measurement
2
2
1
1
79.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist circumference
5
89.5
self reported educational attainment
5
5.9
85.1
macrophage inflammatory protein 1b measurement
2
82.4
mathematical ability
3
81.7
chronotype measurement
1
1
79.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cadherin EGF LAG seven-pass G-type receptor 3
VGNC:7033
460350
Macaque
cadherin EGF LAG seven-pass G-type receptor 3
709315
Mouse
MGI:1858236
107934
Rat
RGD:621787
83466
Dog
cadherin EGF LAG seven-pass G-type receptor 3
VGNC:54589
476635
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cadherin EGF LAG seven-pass G-type receptor 3
Macaque
cadherin EGF LAG seven-pass G-type receptor 3
Mouse
Rat
Dog
cadherin EGF LAG seven-pass G-type receptor 3
Publication Statistics
PubMed Score 48.79
PubMed score by year
PubTator Score 11.41
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title