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Tbio
CELSR3
Cadherin EGF LAG seven-pass G-type receptor 3

Protein Summary
Description
Receptor that may have an important role in cell/cell signaling during nervous system formation. This gene belongs to the flamingo subfamily, which is included in the cadherin superfamily. The flamingo cadherins consist of nonclassic-type cadherins that do not interact with catenins. They are plasma membrane proteins containing seven epidermal growth factor-like repeats, nine cadherin domains and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic feature of their subfamily. The encoded protein may be involved in the regulation of contact-dependent neurite growth and may play a role in tumor formation. [provided by RefSeq, Jun 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000164024
  • ENSP00000164024
  • ENSG00000008300

Symbol
  • CDHF11
  • EGFL1
  • FMI1
  • KIAA0812
  • MEGF2
  • FMI1
  • EGFL1
  • HFMI1
  • MEGF2
  • ADGRC3
  • CDHF11
  • RESDA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor binding site profile
0.92
transcription factor perturbation
0.84
kinase perturbation
0.81
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.19   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 293   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.19   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 293   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0