Protein Summary
Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids. This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
- ENST00000325945
- ENSP00000316339
- ENSG00000116882
- ENST00000361035
- ENSP00000354314
- ENST00000622548
- ENSP00000483507
- HAOX2
- GIG16
- HAOX2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.81 | ||
cellular component | 0.74 | ||
gene perturbation | 0.68 | ||
cell type or tissue | 0.67 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.1 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 105 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 37.1 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 105 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 9
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 1
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0