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Tbio
DONSON
Protein downstream neighbor of Son

Protein Summary
Description
Replisome component that maintains genome stability by protecting stalled or damaged replication forks. After the induction of replication stress, required for the stabilization of stalled replication forks, the efficient activation of the intra-S-phase and G/2M cell-cycle checkpoints and the maintenance of genome stability. This gene lies downstream of the SON gene and spans 10 kb on chromosome 21. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000303071
  • ENSP00000307143
  • ENSG00000159147

Symbol
  • C21orf60
  • B17
  • MIMIS
  • MISSLA
  • C21orf60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
virus perturbation
0.72
cell type or tissue
0.65
disease perturbation
0.62
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 68   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19.12   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 68   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
34.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
34.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
downstream neighbor of SON
VGNC:1158
746652
Macaque
downstream neighbor of SON
698853
Mouse
MGI:1890621
60364
Rat
RGD:1306823
288257
Dog
protein downstream neighbor of Son
100856622
Species
Name
OMA
EggNOG
Inparanoid
Chimp
downstream neighbor of SON
Macaque
downstream neighbor of SON
Mouse
Rat
Dog
protein downstream neighbor of Son
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (97)
1 – 10 of 97
MCM3
Tbio
Novelty: 0.00593382
Score: 0.95
Data Source: STRINGDB
RPA3
Tbio
Novelty: 0.00887858
Score: 0.915
Data Source: STRINGDB
POLA1
Tclin
Family: Enzyme
Novelty: 0.0039096
Score: 0.914
Data Source: STRINGDB
POLD3
Tbio
Family: Enzyme
Novelty: 0.02646621
Score: 0.904
Data Source: STRINGDB
RPA2
Tbio
Novelty: 0.00879115
Score: 0.904
Data Source: STRINGDB
RPA1
Tchem
Novelty: 0.00212665
Score: 0.903
Data Source: STRINGDB
RPA4
Tbio
Novelty: 0.07275015
Score: 0.902
Data Source: STRINGDB
PCNA
Tchem
Novelty: 0.03909539
Score: 0.879
Data Source: STRINGDB
GART
Tclin
Novelty: 0.00524985
Score: 0.828
Data Source: STRINGDB
CHAF1B
Tbio
Novelty: 0.05899435
Score: 0.813
Data Source: STRINGDB
Publication Statistics
PubMed Score  19.12

PubMed score by year
PubTator Score  3.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer