MAP3K20
Mitogen-activated protein kinase kinase kinase 20
Protein Summary
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189). This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The pr ...more
- ENST00000338983
- ENSP00000340257
- ENSG00000091436
- ENST00000375213
- ENSP00000364361
- ENST00000409176
- ENSP00000387259
- ENST00000539448
- ENSP00000439414
- MLTK
- ZAK
- pk
- AZK
- MLT
- MRK
- ZAK
- CNM6
- MLK7
- MLTK
- SFMMP
- mlklak
- MLTKbeta
- MLTKalpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0 | ||
biological term | 0 | ||
cell line | 0 | ||
cell type or tissue | 0 | ||
cellular component | 0 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.1 (req: < 5)
Gene RIFs: 19 (req: <= 3)
Antibodies: 270 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 16.1 (req: >= 5)
Gene RIFs: 19 (req: > 3)
Antibodies: 270 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 29
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (29)
Protein-Protein Interactions (20)
ZNF544
Family: TF
Novelty: 0.99233516
p_int: 0.999999953
p_ni: 4.7e-8
Score: 0.642
Data Source: BioPlex,STRINGDB
ZNF227
Family: TF
Novelty: 2.78882514
p_int: 0.999998116
p_ni: 0.000001883
Score: 0.513
Data Source: BioPlex,STRINGDB
ZNF71
Family: TF
Novelty: 0.24703192
p_int: 0.884231373
p_ni: 0.010571824
p_wrong: 0.105196804
Score: 0.234
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (2)
Downstream (2)
1 – 2 of 2
Pathways (12)
KEGG (1)
PathwayCommons (1)
WikiPathways (10)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
KEGG | MAPK signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
MAPK signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (5)
Components (3)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Disease Associations ()
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 2 | 2 | 83.8 | |||||
mathematical ability | 4 | 3 | 5 | 78.4 | |||||
age at first sexual intercourse measurement | 1 | 1 | 1 | 64.4 | |||||
self reported educational attainment | 1 | 2 | 2 | 62.5 | |||||
cognitive function measurement | 1 | 1 | 1 | 53.7 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 2 | 83.8 | |||||
mathematical ability | 5 | 78.4 | |||||
age at first sexual intercourse measurement | 1 | 64.4 | |||||
self reported educational attainment | 2 | 62.5 | |||||
cognitive function measurement | 1 | 53.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 20 | 698274 | ||||||
Mouse | MGI:2443258 | 65964 | ||||||
Dog | mitogen-activated protein kinase kinase kinase 20 | VGNC:53099 | 478802 | |||||
Platypus | mitogen-activated protein kinase kinase kinase 20 | 100084257 | ||||||
Zebrafish | ZDB-GENE-070912-386 | 405768 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | mitogen-activated protein kinase kinase kinase 20 | |||||
Mouse | ||||||
Dog | mitogen-activated protein kinase kinase kinase 20 | |||||
Platypus | mitogen-activated protein kinase kinase kinase 20 | |||||
Zebrafish | ||||||
Publication Statistics
PubMed Score 16.10
PubMed score by year
PubTator Score 229.94
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (40)
GeneRif Annotations (19)
Items per page:
0 of 0
PMID | Year | Title |
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