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Tchem
MAP3K20
Mitogen-activated protein kinase kinase kinase 20

Protein Summary
Description
Stress-activated component of a protein kinase signal transduction cascade. Regulates the JNK and p38 pathways. Part of a signaling cascade that begins with the activation of the adrenergic receptor ADRA1B and leads to the activation of MAPK14. Pro-apoptotic. Role in regulation of S and G2 cell cycle checkpoint by direct phosphorylation of CHEK2 (PubMed:10924358, PubMed:11836244, PubMed:15342622, PubMed:21224381). Involved in limb development (PubMed:26755636). Isoform 1: Phosphorylates histone H3 at 'Ser-28' (PubMed:15684425). May have role in neoplastic cell transformation and cancer development (PubMed:15172994). Causes cell shrinkage and disruption of actin stress fibers (PubMed:11042189). This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338983
  • ENSP00000340257
  • ENSG00000091436
  • ENST00000375213
  • ENSP00000364361
  • ENST00000409176
  • ENSP00000387259
  • ENST00000539448
  • ENSP00000439414

Symbol
  • MLTK
  • ZAK
  • pk
  • AZK
  • MLT
  • MRK
  • ZAK
  • CNM6
  • MLK7
  • MLTK
  • SFMMP
  • mlklak
  • MLTKbeta
  • MLTKalpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.1   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 29
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (29)
1 – 10 of 29
AST-487
Rendered image for AST-487
motesanib
Rendered image for motesanib
compound 15b [PMID: 16539403]
Rendered image for compound 15b [PMID: 16539403]
CHEMBL4450810
Rendered image for CHEMBL4450810
CHEMBL4098896
Rendered image for CHEMBL4098896
CHEMBL4524151
Rendered image for CHEMBL4524151
CHEMBL4542865
Rendered image for CHEMBL4542865
CHEMBL4526537
Rendered image for CHEMBL4526537
CHEMBL4574656
Rendered image for CHEMBL4574656
CHEMBL4579609
Rendered image for CHEMBL4579609
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
2
2
83.8
mathematical ability
4
3
5
78.4
age at first sexual intercourse measurement
1
1
1
64.4
self reported educational attainment
1
2
2
62.5
cognitive function measurement
1
1
1
53.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
2
83.8
mathematical ability
5
78.4
age at first sexual intercourse measurement
1
64.4
self reported educational attainment
2
62.5
cognitive function measurement
1
53.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 20
698274
Mouse
MGI:2443258
65964
Dog
mitogen-activated protein kinase kinase kinase 20
VGNC:53099
478802
Platypus
mitogen-activated protein kinase kinase kinase 20
100084257
Zebrafish
ZDB-GENE-070912-386
405768
Species
Name
OMA
EggNOG
Inparanoid
Macaque
mitogen-activated protein kinase kinase kinase 20
Mouse
Dog
mitogen-activated protein kinase kinase kinase 20
Platypus
mitogen-activated protein kinase kinase kinase 20
Zebrafish
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYL2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (23)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (20)
1 – 10 of 20
ZNF544
Tdark
Family:  TF
Novelty:  0.99233516
p_int:  0.999999953
p_ni:  4.7e-8
Score:  0.642
Data Source:  BioPlex,STRINGDB
ZNF227
Tdark
Family:  TF
Novelty:  2.78882514
p_int:  0.999998116
p_ni:  0.000001883
Score:  0.513
Data Source:  BioPlex,STRINGDB
ZNF71
Tbio
Family:  TF
Novelty:  0.24703192
p_int:  0.884231373
p_ni:  0.010571824
p_wrong:  0.105196804
Score:  0.234
Data Source:  BioPlex,STRINGDB
PKN1
Tchem
Family:  Kinase
Novelty:  0.00780975
Score:  0.951
Data Source:  STRINGDB
MAP2K6
Tchem
Family:  Kinase
Novelty:  0.00569655
Score:  0.947
Data Source:  STRINGDB
MAP2K7
Tchem
Family:  Kinase
Novelty:  0.00916401
Score:  0.897
Data Source:  STRINGDB
ZNF33A
Tbio
Family:  TF
Novelty:  0.14568295
Score:  0.823
Data Source:  STRINGDB
ZNF567
Tdark
Family:  TF
Novelty:  1.90648197
Score:  0.703
Data Source:  STRINGDB
MAP2K4
Tchem
Family:  Kinase
Novelty:  0.00252847
Score:  0.595
Data Source:  STRINGDB
SLC25A20
Tbio
Family:  Transporter
Novelty:  0.00503518
Score:  0.531
Data Source:  STRINGDB
Publication Statistics
PubMed Score  16.10

PubMed score by year
PubTator Score  229.94

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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