You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MRPL39
39S ribosomal protein L39, mitochondrial

Protein Classes
Protein Summary
Description
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Two transcript variants encoding distinct isoforms have been described. A pseudogene corresponding to this gene is found on chromosome 5q. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000307301
  • ENSP00000305682
  • ENSG00000154719
  • ENST00000352957
  • ENSP00000284967

Symbol
  • C21orf92
  • MRPL5
  • RPML5
  • L39mt
  • MRPL5
  • RPML5
  • MRP-L5
  • PRED22
  • PRED66
  • MSTP003
  • C21orf92
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.97
transcription factor binding site profile
0.89
histone modification site profile
0.87
transcription factor perturbation
0.8


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.45   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L39
VGNC:1142
458485
Macaque
mitochondrial ribosomal protein L39
708631
Mouse
MGI:1351620
27393
Dog
mitochondrial ribosomal protein L39
VGNC:43396
487709
Horse
mitochondrial ribosomal protein L39 [Source:HGNC Symbol;Acc:HGNC:14027]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
mitochondrial ribosomal protein L39
Macaque
mitochondrial ribosomal protein L39
Mouse
Dog
mitochondrial ribosomal protein L39
Horse
mitochondrial ribosomal protein L39 [Source:HGNC Symbol;Acc:HGNC:14027]
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYK5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Mitochondrial translation
Reactome
Mitochondrial translation elongation
Reactome
Mitochondrial translation initiation
Reactome
Mitochondrial translation termination
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Mitochondrial translation
Mitochondrial translation elongation
Mitochondrial translation initiation
Mitochondrial translation termination
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (208)
1 – 10 of 208
MRPS30
Tbio
Novelty: 0.08115544
p_int: 0.999977237
p_ni: 0.000022763
Score: 0.984
Data Source: BioPlex,STRINGDB
MRPL47
Tbio
Novelty: 0.05648009
p_int: 0.999951584
p_ni: 0.000048416
Score: 0.99
Data Source: BioPlex,STRINGDB
MRPL28
Tdark
Novelty: 0.23845162
p_int: 0.999267522
p_ni: 0.000732478
Score: 0.991
Data Source: BioPlex,STRINGDB
MRPL42
Tbio
Novelty: 0.48241447
p_int: 0.998870188
p_ni: 0.001129812
Score: 0.992
Data Source: BioPlex,STRINGDB
MRPL40
Tbio
Novelty: 0.09916967
p_int: 0.99851605
p_ni: 0.00148395
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL10
Tbio
Novelty: 0.27087019
p_int: 0.99829834
p_ni: 0.00170166
Score: 0.983
Data Source: BioPlex,STRINGDB
MRPL50
Tdark
Novelty: 0.88879319
p_int: 0.99769991
p_ni: 0.00230009
Score: 0.991
Data Source: BioPlex,STRINGDB
MRPL24
Tdark
Novelty: 0.61597737
p_int: 0.995937563
p_ni: 0.004062437
Score: 0.987
Data Source: BioPlex,STRINGDB
MRPL38
Tdark
Novelty: 0.71587283
p_int: 0.995357993
p_ni: 0.004642007
Score: 0.988
Data Source: BioPlex,STRINGDB
MRPL4
Tdark
Novelty: 0.27290276
p_int: 0.992496991
p_ni: 0.007503009
Score: 0.99
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  5.45

PubMed score by year
PubTator Score  1.27

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer