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Tclin
TLR7
Toll-like receptor 7

Protein Summary
Description
Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is predominantly expressed in lung, placenta, and spleen, and lies ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380659
  • ENSP00000370034
  • ENSG00000196664

Symbol
  • TLR7-like
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.97
biological process
0.94
protein domain
0.92
phenotype
0.67
disease
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.34   (req: < 5)
Gene RIFs: 258   (req: <= 3)
Antibodies: 937   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1632.34   (req: >= 5)
Gene RIFs: 258   (req: > 3)
Antibodies: 937   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 54
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Pathways (20)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
MyD88 dependent cascade initiated on endosome
Reactome
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
Reactome
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
MyD88 dependent cascade initiated on endosome
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
Gene Ontology Terms (39)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (412)
1 – 10 of 412
MYD88
Tbio
Novelty: 0.00054413
Score: 0.995
Data Source: Reactome,STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.00308898
Score: 0.987
Data Source: Reactome,STRINGDB
UNC93B1
Tbio
Novelty: 0.01966959
Score: 0.985
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00254228
Score: 0.976
Data Source: Reactome,STRINGDB
IRAK4
Tchem
Family: Kinase
Novelty: 0.00479185
Score: 0.974
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00159491
Score: 0.973
Data Source: Reactome,STRINGDB
CTSS
Tchem
Family: Enzyme
Novelty: 0.00788672
Score: 0.963
Data Source: STRINGDB
IRAK2
Tbio
Family: Kinase
Novelty: 0.02755088
Score: 0.962
Data Source: Reactome,STRINGDB
TLR8
Tchem
Novelty: 0.00120893
Score: 0.956
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00167817
Score: 0.951
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  1632.34

PubMed score by year
PubTator Score  946.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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