Tbio TAB2 TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Protein Summary

Description

Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

Uniprot Accession IDs

• Q9NYJ8
• B2RCC4
• E1P5A0
• O94838
• Q6I9W8
• Q76N06
• Q9UFP7

Gene Name

• TAB2

Ensembl ID

• ENST00000367456
• ENSP00000356426
• ENSG00000055208
• ENST00000470466
• ENSP00000432709
• ENST00000538427
• ENSP00000445752
• ENST00000637181
• ENSP00000490618

Symbol

• KIAA0733
• MAP3K7IP2
• CHTD2
• TAB-2
• MAP3K7IP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
disease perturbation	0.93
transcription factor perturbation	0.91
biological process	0.88
microRNA	0.82

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.3   (req: < 5)

Gene RIFs: 56   (req: <= 3)

Antibodies: 195   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.3   (req: >= 5)

Gene RIFs: 56   (req: > 3)

Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0