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Tbio
TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

Protein Summary
Description
Adapter linking MAP3K7/TAK1 and TRAF6. Promotes MAP3K7 activation in the IL1 signaling pathway. The binding of 'Lys-63'-linked polyubiquitin chains to TAB2 promotes autophosphorylation of MAP3K7 at 'Thr-187'. Involved in heart development. The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, and it thus serves as an adaptor that links MAP3K7 and TRAF6. This protein, along with TAB1 and MAP3K7, also participates in the signal transduction induced by TNFSF11/RANKl through the activation of the receptor activator of NF-kappaB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts. Studies of the related mouse protein indicate that it functions to protect against liver damage caused by chemical stressors. Mutations in this gene cause congenital heart defects, multiple types, 2 (CHTD2). Alternativ ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367456
  • ENSP00000356426
  • ENSG00000055208
  • ENST00000470466
  • ENSP00000432709
  • ENST00000538427
  • ENSP00000445752
  • ENST00000637181
  • ENSP00000490618

Symbol
  • KIAA0733
  • MAP3K7IP2
  • CHTD2
  • TAB-2
  • MAP3K7IP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.98
disease perturbation
0.93
transcription factor perturbation
0.91
biological process
0.88
microRNA
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.01   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 195   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 150.01   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 195   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
75.7
1
1
0
1.1
34.5
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
75.7
0
1.1
34.5
1
11.6
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
TGF-beta activated kinase 1/MAP3K7 binding protein 2
696875
Mouse
MGI:1915902
68652
Rat
RGD:1309527
308267
Dog
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
VGNC:53995
484028
Horse
TGF-beta activated kinase 1/MAP3K7 binding protein 2
100060433
Species
Name
OMA
EggNOG
Inparanoid
Macaque
TGF-beta activated kinase 1/MAP3K7 binding protein 2
Mouse
Rat
Dog
TGF-beta activated kinase 1 (MAP3K7) binding protein 2
Horse
TGF-beta activated kinase 1/MAP3K7 binding protein 2
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYJ8-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (253)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CLEC7A (Dectin-1) signaling
Reactome
Cytokine Signaling in Immune system
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
C-type lectin receptors (CLRs)
CLEC7A (Dectin-1) signaling
Cytokine Signaling in Immune system
Death Receptor Signalling
Protein-Protein Interactions (210)
1 – 10 of 210
TAB1
Tchem
Family: Kinase
Novelty: 0.00721424
p_int: 0.999999992
p_ni: 8e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.99999994
p_ni: 3.7e-8
p_wrong: 2.3e-8
Data Source: BioPlex
SCRN1
Tbio
Family: Enzyme
Novelty: 0.08315012
p_int: 0.999988538
p_ni: 0.000011462
Score: 0.189
Data Source: BioPlex,STRINGDB
CARNMT1
Tbio
Family: Enzyme
Novelty: 0.28121779
p_int: 0.999466699
p_ni: 0.000529542
p_wrong: 0.000003759
Data Source: BioPlex
CCDC102B
Tdark
Novelty: 0.28075569
p_int: 0.998643994
p_ni: 0.001356003
p_wrong: 4e-9
Data Source: BioPlex
HSPA14
Tbio
Novelty: 0.01714625
p_int: 0.998584553
p_ni: 0.001415342
p_wrong: 1.04e-7
Data Source: BioPlex
MANSC1
Tdark
Novelty: 0.91681036
p_int: 0.996923689
p_ni: 0.002966311
p_wrong: 0.00011
Data Source: BioPlex
PCDHGB2
Tdark
Novelty: 1.16587709
p_int: 0.987146239
p_ni: 0.01284366
p_wrong: 0.0000101
Data Source: BioPlex
RFPL4B
Tdark
Novelty: 2.42779597
p_int: 0.930910502
p_ni: 0.013747184
p_wrong: 0.055342314
Score: 0.186
Data Source: BioPlex,STRINGDB
CARD8
Tbio
Family: Enzyme
Novelty: 0.0146799
p_int: 0.902399035
p_ni: 0.001385587
p_wrong: 0.096215378
Data Source: BioPlex
Publication Statistics
PubMed Score  150.01

PubMed score by year
PubTator Score  15.09

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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