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Tbio
DLL3
Delta-like protein 3

Protein Summary
Description
Inhibits primary neurogenesis. May be required to divert neurons along a specific differentiation pathway. Plays a role in the formation of somite boundaries during segmentation of the paraxial mesoderm (By similarity). This gene encodes a member of the delta protein ligand family. This family functions as Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. Mutations in this gene cause autosomal recessive spondylocostal dysostosis 1. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000205143
  • ENSP00000205143
  • ENSG00000090932
  • ENST00000356433
  • ENSP00000348810

Symbol
  • SCDO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.76
gene perturbation
0.66
histone modification site profile
0.66
protein domain
0.58
PubMedID
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.49   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 121.49   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
2
2
77
myeloid white cell count
1
1
1
62.5
leukocyte count
1
1
1
55.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
77
myeloid white cell count
1
62.5
leukocyte count
1
55.2
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 3
VGNC:10424
736571
Macaque
delta like canonical Notch ligand 3
697453
Mouse
MGI:1096877
13389
Rat
RGD:70953
114125
Dog
delta like canonical Notch ligand 3
VGNC:53689
484508
Species
Name
OMA
EggNOG
Inparanoid
Chimp
delta like canonical Notch ligand 3
Macaque
delta like canonical Notch ligand 3
Mouse
Rat
Dog
delta like canonical Notch ligand 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYJ7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (23)
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Endocrine resistance
KEGG
Breast cancer
KEGG
Th1 and Th2 cell differentiation
KEGG
Pathways in cancer
KEGG
Notch signaling pathway
Name
Explore in Pharos
Explore in Source
Endocrine resistance
Breast cancer
Th1 and Th2 cell differentiation
Pathways in cancer
Notch signaling pathway
Gene Ontology Terms (9)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (50)
1 – 10 of 50
NOTCH1
Tchem
Novelty:  0.00012547
Score:  0.932
Data Source:  STRINGDB
JAG1
Tbio
Novelty:  0.00107618
Score:  0.925
Data Source:  STRINGDB
DLL1
Tbio
Novelty:  0.00150384
Score:  0.918
Data Source:  STRINGDB
NOTCH3
Tchem
Novelty:  0.000953
Score:  0.854
Data Source:  STRINGDB
DLL4
Tbio
Novelty:  0.00263355
Score:  0.839
Data Source:  STRINGDB
RBPJ
Tchem
Family:  TF
Novelty:  0.00168834
Score:  0.784
Data Source:  STRINGDB
HES7
Tbio
Family:  TF
Novelty:  0.02014919
Score:  0.74
Data Source:  STRINGDB
MESP2
Tbio
Family:  TF
Novelty:  0.02601024
Score:  0.718
Data Source:  STRINGDB
NOTCH4
Tchem
Novelty:  0.00471643
Score:  0.712
Data Source:  STRINGDB
LFNG
Tbio
Family:  Enzyme
Novelty:  0.02660238
Score:  0.712
Data Source:  STRINGDB
Publication Statistics
PubMed Score  121.49

PubMed score by year
PubTator Score  69.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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