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Tbio
KCNK4
Potassium channel subfamily K member 4

Protein Summary
Description
Voltage-insensitive potassium channel (PubMed:22282805). Channel opening is triggered by mechanical forces that deform the membrane (PubMed:22282805, PubMed:25471887, PubMed:25500157). Channel opening is triggered by raising the intracellular pH to basic levels (By similarity). The channel is inactive at 24 degrees Celsius (in vitro); raising the temperature to 37 degrees Celsius increases the frequency of channel opening, with a further increase in channel activity when the temperature is raised to 42 degrees Celsius (By similarity). Plays a role in the perception of pain caused by heat (By similarity). Plays a role in the sensory perception of pain caused by pressure (By similarity). This gene encodes a member of the TWIK-related arachidonic acid-stimulated two pore potassium channel subfamily. The encoded protein homodimerizes and functions as an outwardly rectifying channel. This channel is regulated by polyunsaturated fatty acids, temperature and mechanical deformation of the lipi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394525
  • ENSP00000378033
  • ENSG00000182450
  • ENST00000422670
  • ENSP00000402797
  • ENST00000539216
  • ENSP00000444948

Symbol
  • TRAAK
  • TRAAK
  • K2p4.1
  • TRAAK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.88
PubMedID
0.6
biological process
0.59
chemical
0.45
protein domain
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 81.09   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (32)
KCNH3
Tclin
Family:  IC
Novelty:  0.05847445
Score:  0.801
Data Source:  STRINGDB
KCNQ3
Tclin
Family:  IC
Novelty:  0.00547886
Score:  0.753
Data Source:  STRINGDB
PIEZO1
Tchem
Family:  IC
Novelty:  0.00374633
Score:  0.686
Data Source:  STRINGDB
TRPM8
Tclin
Family:  IC
Novelty:  0.00153949
Score:  0.634
Data Source:  STRINGDB
TRPA1
Tclin
Family:  IC
Novelty:  0.00093648
Score:  0.627
Data Source:  STRINGDB
TRPV1
Tclin
Family:  IC
Novelty:  0.00039493
Score:  0.595
Data Source:  STRINGDB
PIEZO2
Tbio
Family:  IC
Novelty:  0.00731622
Score:  0.564
Data Source:  STRINGDB
KCNH4
Tclin
Family:  IC
Novelty:  0.02685071
Score:  0.562
Data Source:  STRINGDB
KCNA1
Tclin
Family:  IC
Novelty:  0.00183322
Score:  0.561
Data Source:  STRINGDB
KCNH8
Tclin
Family:  IC
Novelty:  0.0843705
Score:  0.556
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Neuronal System
Reactome
Phase 4 - resting membrane potential
Reactome
Potassium Channels
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Neuronal System
Phase 4 - resting membrane potential
Potassium Channels
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (20)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (52)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
3
6
7
97.1
BMI-adjusted waist-hip ratio
6
6
10
97.1
urate measurement
1
4
4
94.5
triglyceride measurement
4
3
4
93.5
high density lipoprotein cholesterol measurement
5
3
5
92.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
waist-hip ratio
7
97.1
BMI-adjusted waist-hip ratio
10
97.1
urate measurement
4
94.5
triglyceride measurement
4
93.5
high density lipoprotein cholesterol measurement
5
92.1
Find similar targets by:
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 4
VGNC:7505
743334
Macaque
potassium two pore domain channel subfamily K member 4 [Source:HGNC Symbol;Acc:HGNC:6279]
Mouse
MGI:1298234
16528
Rat
RGD:621449
116489
Dog
potassium two pore domain channel subfamily K member 4
VGNC:42276
612120
Species
Name
OMA
EggNOG
Inparanoid
Chimp
potassium two pore domain channel subfamily K member 4
Macaque
potassium two pore domain channel subfamily K member 4 [Source:HGNC Symbol;Acc:HGNC:6279]
Mouse
Rat
Dog
potassium two pore domain channel subfamily K member 4
Publication Statistics
PubMed Score 81.09
PubMed score by year
PubTator Score 27.73
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Text