ANAPC11
Anaphase-promoting complex subunit 11
Protein Summary
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
- ENST00000344877
- ENSP00000339695
- ENSG00000141552
- ENST00000357385
- ENSP00000349957
- ENST00000392376
- ENSP00000376181
- ENST00000571024
- ENSP00000461648
- ENST00000571570
- ENSP00000458143
- ENST00000571874
- ENSP00000459200
- ENST00000572639
- ENSP00000460678
- ENST00000572851
- ENSP00000458265
- ENST00000574924
- ENSP00000460064
- ENST00000575195
- ENSP00000458515
- ENST00000577747
- ENSP00000463567
- ENST00000578550
- ENSP00000464615
- ENST00000579978
- ENSP00000463640
- ENST00000583839
- ENSP00000463598
- APC11
- Apc11p
- HSPC214
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.94 | ||
virus perturbation | 0.92 | ||
histone modification site profile | 0.8 | ||
disease perturbation | 0.74 | ||
cell type or tissue | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.14 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.14 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (413)
Nearest Tclin Targets (3)
Upstream (3)
1 – 3 of 3
Pathways (45)
Reactome (37)
KEGG (5)
UniProt (1)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | APC-Cdc20 mediated degradation of Nek2A | ||||
Reactome | APC/C-mediated degradation of cell cycle proteins | ||||
Reactome | APC/C:Cdc20 mediated degradation of Cyclin B | ||||
Reactome | APC/C:Cdc20 mediated degradation of Securin | ||||
Reactome | APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
APC-Cdc20 mediated degradation of Nek2A | ||||
APC/C-mediated degradation of cell cycle proteins | ||||
APC/C:Cdc20 mediated degradation of Cyclin B | ||||
APC/C:Cdc20 mediated degradation of Securin | ||||
APC/C:Cdc20 mediated degradation of mitotic proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (18)
Functions (4)
Components (6)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (11)
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
vital capacity | 1 | 1 | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 2 | 3 | 3 | 58.3 | |||||
hematocrit | 2 | 2 | 2 | 55.2 | |||||
hemoglobin measurement | 1 | 1 | 1 | 47.7 | |||||
forced expiratory volume | 1 | 1 | 1 | 46.5 | |||||
Items per page:
1 – 5 of 11
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
vital capacity | 1 | 73.2 | |||||
BMI-adjusted waist-hip ratio | 3 | 58.3 | |||||
hematocrit | 2 | 55.2 | |||||
hemoglobin measurement | 1 | 47.7 | |||||
forced expiratory volume | 1 | 46.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | anaphase promoting complex subunit 11 | VGNC:6334 | 454972 | |||||
Macaque | anaphase promoting complex subunit 11 | 714909 | ||||||
Mouse | MGI:1913406 | 66156 | ||||||
Dog | anaphase promoting complex subunit 11 | VGNC:51919 | 483370 | |||||
Cow | anaphase promoting complex subunit 11 | 616275 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | anaphase promoting complex subunit 11 | |||||
Macaque | anaphase promoting complex subunit 11 | |||||
Mouse | ||||||
Dog | anaphase promoting complex subunit 11 | |||||
Cow | anaphase promoting complex subunit 11 | |||||
Publication Statistics
PubMed Score 34.14
PubMed score by year
PubTator Score 19.61
PubTator score by year
Related Publications
Text Mined References (30)
GeneRif Annotations (5)
Items per page:
0 of 0
PMID | Year | Title |
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