ANAPC11
Anaphase-promoting complex subunit 11
Protein Summary
Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.
- ENST00000344877
- ENSP00000339695
- ENSG00000141552
- ENST00000357385
- ENSP00000349957
- ENST00000392376
- ENSP00000376181
- ENST00000571024
- ENSP00000461648
- ENST00000571570
- ENSP00000458143
- ENST00000571874
- ENSP00000459200
- ENST00000572639
- ENSP00000460678
- ENST00000572851
- ENSP00000458265
- ENST00000574924
- ENSP00000460064
- ENST00000575195
- ENSP00000458515
- ENST00000577747
- ENSP00000463567
- ENST00000578550
- ENSP00000464615
- ENST00000579978
- ENSP00000463640
- ENST00000583839
- ENSP00000463598
- APC11
- Apc11p
- HSPC214
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.94 | ||
virus perturbation | 0.92 | ||
histone modification site profile | 0.8 | ||
disease perturbation | 0.74 | ||
cell type or tissue | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.07 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 41.07 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0