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Tbio
ZDHHC3
Palmitoyltransferase ZDHHC3

Protein Summary
Description
Palmitoyltransferase with broad specificity (PubMed:21926431, PubMed:23034182). Palmitoylates GABA receptors on their gamma subunit (GABRG1, GABRG2 and GABRG3), which regulates synaptic clustering and/or cell surface stability (By similarity). Palmitoylates glutamate receptors GRIA1 and GRIA2, which leads to their retention in Golgi. May also palmitoylate DLG4, DNAJC5 and SNAP25 (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296127
  • ENSP00000296127
  • ENSG00000163812
  • ENST00000424952
  • ENSP00000395502
  • ENST00000628351
  • ENSP00000486386
  • ENSG00000280674
  • ENST00000630389
  • ENSP00000485706

Symbol
  • GODZ
  • DHHC3
  • DHHC-3
  • ZNF373
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
histone modification site profile
0.86
kinase perturbation
0.84
transcription factor perturbation
0.84
tissue sample
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 116   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.94   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 116   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0