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Tbio
BCLAF1
Bcl-2-associated transcription factor 1

Protein Summary
Description
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000353331
  • ENSP00000229446
  • ENSG00000029363
  • ENST00000392348
  • ENSP00000376159
  • ENST00000527759
  • ENSP00000434826
  • ENST00000530767
  • ENSP00000436501
  • ENST00000531224
  • ENSP00000435210

Symbol
  • BTF
  • KIAA0164
  • BTF
  • bK211L9.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
1
interacting protein
1
transcription factor perturbation
0.97
transcription factor binding site profile
0.94
hub protein
0.92


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.27   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 281   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.27   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 281   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (111)
1 – 10 of 111
CLK2
Tchem
Family:  Kinase
Novelty:  0.13068449
p_int:  0.993636665
p_ni:  0.006363335
Score:  0.732
Data Source:  BioPlex,STRINGDB
ERH
Tbio
Novelty:  0.00711649
p_int:  0.993598491
p_ni:  0.006401509
Score:  0.503
Data Source:  BioPlex,STRINGDB
SAP18
Tbio
Family:  Enzyme
Novelty:  0.03918373
p_int:  0.991281915
p_ni:  0.008718085
Score:  0.264
Data Source:  BioPlex,STRINGDB
SNRNP70
Tbio
Novelty:  0.00116631
p_int:  0.987444316
p_ni:  0.012555684
Score:  0.457
Data Source:  BioPlex,STRINGDB
SNIP1
Tbio
Novelty:  0.01865867
p_int:  0.969814333
p_ni:  0.030185667
Score:  0.685
Data Source:  BioPlex,STRINGDB
LUC7L2
Tdark
Novelty:  0.36989457
p_int:  0.961290093
p_ni:  0.038709907
Score:  0.237
Data Source:  BioPlex,STRINGDB
PNN
Tbio
Novelty:  0.01395394
p_int:  0.947388808
p_ni:  0.052611192
Score:  0.776
Data Source:  BioPlex,STRINGDB
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.938491276
p_ni:  0.061508725
Data Source:  BioPlex
PRMT8
Tchem
Family:  Epigenetic
Novelty:  0.04213384
p_int:  0.934774799
p_ni:  0.065225201
Data Source:  BioPlex
RNASEH1
Tchem
Family:  Enzyme
Novelty:  0.01838314
p_int:  0.920572197
p_ni:  0.079427803
Data Source:  BioPlex
Pathways (1)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Interactome of polycomb repressive complex 2 (PRC2)
Name
Explore in Pharos
Explore in Source
Interactome of polycomb repressive complex 2 (PRC2)
Gene Ontology Terms (14)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated transcription factor 1
VGNC:7163
463020
Macaque
BCL2 associated transcription factor 1
705705
Mouse
MGI:1917580
72567
Dog
BCL2 associated transcription factor 1
VGNC:38415
483999
Horse
BCL2 associated transcription factor 1
VGNC:15798
100067787
Species
Name
OMA
EggNOG
Inparanoid
Chimp
BCL2 associated transcription factor 1
Macaque
BCL2 associated transcription factor 1
Mouse
Dog
BCL2 associated transcription factor 1
Horse
BCL2 associated transcription factor 1
Publication Statistics
PubMed Score 69.27
PubMed score by year
PubTator Score 27.22
PubTator score by year