BCLAF1
Bcl-2-associated transcription factor 1
Protein Summary
Death-promoting transcriptional repressor. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. This gene encodes a transcriptional repressor that interacts with several members of the BCL2 family of proteins. Overexpression of this protein induces apoptosis, which can be suppressed by co-expression of BCL2 proteins. The protein localizes to dot-like structures throughout the nucleus, and redistributes to a zone near the nuclear envelope in cells undergoing apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- ENST00000353331
- ENSP00000229446
- ENSG00000029363
- ENST00000392348
- ENSP00000376159
- ENST00000527759
- ENSP00000434826
- ENST00000530767
- ENSP00000436501
- ENST00000531224
- ENSP00000435210
- BTF
- KIAA0164
- BTF
- bK211L9.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 1 | ||
interacting protein | 1 | ||
transcription factor perturbation | 0.97 | ||
transcription factor binding site profile | 0.94 | ||
hub protein | 0.92 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.02 (req: < 5)
Gene RIFs: 29 (req: <= 3)
Antibodies: 281 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.02 (req: >= 5)
Gene RIFs: 29 (req: > 3)
Antibodies: 281 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0