Protein Summary
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway ...more
- ENST00000335867
- ENSP00000337439
- ENSG00000165617
- ENST00000395153
- ENSP00000378582
- DPR1
- HNG3
- DPR1
- TBS2
- FRODO
- HDPR1
- DAPPER
- THYEX3
- DAPPER1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.93 | ||
PubMedID | 0.79 | ||
histone modification site profile | 0.72 | ||
transcription factor | 0.7 | ||
interacting protein | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 320.52 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 139 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 320.52 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 139 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 1 | 1 | 45 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
testosterone measurement | 1 | 45 | |||||
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 1 | VGNC:10304 | 452938 | |||||
Macaque | dishevelled binding antagonist of beta catenin 1 | 701218 | ||||||
Mouse | MGI:1891740 | 59036 | ||||||
Rat | RGD:1564008 | 500666 | ||||||
Dog | dishevelled binding antagonist of beta catenin 1 | VGNC:39761 | 100687551 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 1 | |||||
Macaque | dishevelled binding antagonist of beta catenin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dishevelled binding antagonist of beta catenin 1 | |||||
Pathways (5)
Reactome (4)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of DVL | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of DVL | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Gene Ontology Terms (31)
Functions (6)
Components (6)
Processes (19)
Items per page:
10
1 – 6 of 6
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Protein-Protein Interactions (64)
1 – 10 of 64
DVL2
Novelty: 0.00833084
Score: 0.989
Data Source: Reactome,STRINGDB
VANGL2
Novelty: 0.00529796
Score: 0.948
Data Source: STRINGDB
CTNNB1
Novelty: 0.0000744
Score: 0.77
Data Source: STRINGDB
SESTD1
Novelty: 0.2052002
Score: 0.708
Data Source: STRINGDB
ZBTB17
Family: TF
Novelty: 0.0503245
Score: 0.661
Data Source: STRINGDB
LRRC17
Novelty: 0.16875862
Score: 0.655
Data Source: STRINGDB
PTK7
Family: Kinase
Novelty: 0.00251552
Score: 0.652
Data Source: STRINGDB
VANGL1
Novelty: 0.00968008
Score: 0.649
Data Source: STRINGDB
CAVIN4
Novelty: 0.03177065
Score: 0.643
Data Source: STRINGDB
DVL1
Novelty: 0.00356876
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score 320.52
PubMed score by year
PubTator Score 42.88
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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