Protein Summary
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway ...more
- ENST00000335867
- ENSP00000337439
- ENSG00000165617
- ENST00000395153
- ENSP00000378582
- DPR1
- HNG3
- DPR1
- TBS2
- FRODO
- HDPR1
- DAPPER
- THYEX3
- DAPPER1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 0.93 | ||
PubMedID | 0.79 | ||
histone modification site profile | 0.72 | ||
transcription factor | 0.7 | ||
interacting protein | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 323.47 (req: < 5)
Gene RIFs: 26 (req: <= 3)
Antibodies: 139 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 323.47 (req: >= 5)
Gene RIFs: 26 (req: > 3)
Antibodies: 139 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 25
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (64)
Nearest Tclin Targets
Pathways (5)
Reactome (4)
PathwayCommons (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Degradation of DVL | ||||
Reactome | Signal Transduction | ||||
Reactome | Signaling by WNT | ||||
Reactome | TCF dependent signaling in response to WNT | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Degradation of DVL | ||||
Signal Transduction | ||||
Signaling by WNT | ||||
TCF dependent signaling in response to WNT | ||||
Viral Interactions (0)
Gene Ontology Terms (31)
Functions (6)
Components (6)
Processes (19)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Physical Interaction (IPI) | ParkinsonsUK-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
cortical surface area measurement | 1 | 4 | 0 | 9.2 | 77.6 | ||||
cortical thickness | 1 | 2 | 2 | 67.3 | |||||
2 | 2 | 0 | 1.1 | 59.4 | |||||
1 | 2 | 0 | 1.1 | 59.4 | |||||
waist-hip ratio | 1 | 1 | 1 | 33.1 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
cortical surface area measurement | 0 | 9.2 | 77.6 | ||||
cortical thickness | 2 | 67.3 | |||||
0 | 1.1 | 59.4 | |||||
0 | 1.1 | 59.4 | |||||
waist-hip ratio | 1 | 33.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 1 | VGNC:10304 | 452938 | |||||
Macaque | dishevelled binding antagonist of beta catenin 1 | 701218 | ||||||
Mouse | MGI:1891740 | 59036 | ||||||
Rat | RGD:1564008 | 500666 | ||||||
Dog | dishevelled binding antagonist of beta catenin 1 | VGNC:39761 | 100687551 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | dishevelled binding antagonist of beta catenin 1 | |||||
Macaque | dishevelled binding antagonist of beta catenin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | dishevelled binding antagonist of beta catenin 1 | |||||
Publication Statistics
PubMed Score 323.47
PubMed score by year
PubTator Score 42.88
PubTator score by year
Related Publications
Text Mined References (35)
GeneRif Annotations (26)
Items per page:
0 of 0
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