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Tbio
DACT1
Dapper homolog 1

Protein Summary
Description
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335867
  • ENSP00000337439
  • ENSG00000165617
  • ENST00000395153
  • ENSP00000378582

Symbol
  • DPR1
  • HNG3
  • DPR1
  • TBS2
  • FRODO
  • HDPR1
  • DAPPER
  • THYEX3
  • DAPPER1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
PubMedID
0.79
histone modification site profile
0.72
transcription factor
0.7
interacting protein
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.52   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 320.52   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
1
1
45
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
45
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dishevelled binding antagonist of beta catenin 1
VGNC:10304
452938
Macaque
dishevelled binding antagonist of beta catenin 1
701218
Mouse
MGI:1891740
59036
Rat
RGD:1564008
500666
Dog
dishevelled binding antagonist of beta catenin 1
VGNC:39761
100687551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dishevelled binding antagonist of beta catenin 1
Macaque
dishevelled binding antagonist of beta catenin 1
Mouse
Rat
Dog
dishevelled binding antagonist of beta catenin 1
Pathways (5)
Degradation of DVL (R-HSA-4641258)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of DVL
Reactome
Signal Transduction
Reactome
Signaling by WNT
Reactome
TCF dependent signaling in response to WNT
Name
Explore in Pharos
Explore in Source
Degradation of DVL
Signal Transduction
Signaling by WNT
TCF dependent signaling in response to WNT
Gene Ontology Terms (31)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (64)
1 – 10 of 64
DVL2
Tbio
Novelty: 0.00833084
Score: 0.989
Data Source: Reactome,STRINGDB
VANGL2
Tbio
Novelty: 0.00529796
Score: 0.948
Data Source: STRINGDB
CTNNB1
Tchem
Novelty: 0.0000744
Score: 0.77
Data Source: STRINGDB
SESTD1
Tbio
Novelty: 0.2052002
Score: 0.708
Data Source: STRINGDB
ZBTB17
Tbio
Family: TF
Novelty: 0.0503245
Score: 0.661
Data Source: STRINGDB
LRRC17
Tdark
Novelty: 0.16875862
Score: 0.655
Data Source: STRINGDB
PTK7
Tbio
Family: Kinase
Novelty: 0.00251552
Score: 0.652
Data Source: STRINGDB
VANGL1
Tbio
Novelty: 0.00968008
Score: 0.649
Data Source: STRINGDB
CAVIN4
Tbio
Novelty: 0.03177065
Score: 0.643
Data Source: STRINGDB
DVL1
Tchem
Novelty: 0.00356876
Score: 0.641
Data Source: STRINGDB
Publication Statistics
PubMed Score  320.52

PubMed score by year
PubTator Score  42.88

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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