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Tdark
DNAH9
Dynein heavy chain 9, axonemal

Protein Summary
Description
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. This gene encodes the heavy chain subunit of axonemal dynein, a large multi-subunit molecular motor. Axonemal dynein attaches to microtubules and hydrolyzes ATP to mediate the movement of cilia and flagella. The gene expresses at least two transcript variants; additional variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262442
  • ENSP00000262442
  • ENSG00000007174
  • ENST00000608377
  • ENSP00000476951

Symbol
  • DNAH17L
  • DNAL1
  • KIAA0357
  • DYH9
  • HL20
  • DNEL1
  • HL-20
  • CILD40
  • Dnahc9
  • DNAH17L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
molecular function
0.93
trait
0.75
cellular component
0.66
tissue sample
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 39   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20.13   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 39   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (107)
1 – 10 of 107
DNAI1
Tbio
Novelty: 0.01021193
Score: 0.908
Data Source: STRINGDB
DNAI2
Tbio
Novelty: 0.02801096
Score: 0.907
Data Source: STRINGDB
DNALI1
Tbio
Novelty: 0.13865981
Score: 0.899
Data Source: STRINGDB
DNAL4
Tbio
Novelty: 0.15546154
Score: 0.877
Data Source: STRINGDB
DYNLL2
Tbio
Novelty: 0.11209457
Score: 0.803
Data Source: STRINGDB
CCDC114
Tbio
Novelty: 0.12534741
Score: 0.798
Data Source: STRINGDB
DYNLL1
Tbio
Novelty: 0.00397334
Score: 0.785
Data Source: STRINGDB
DNAH12
Tbio
Novelty: 0.02743114
Score: 0.785
Data Source: STRINGDB
NME8
Tbio
Novelty: 0.05439119
Score: 0.782
Data Source: STRINGDB
DNAL1
Tbio
Novelty: 0.00168166
Score: 0.769
Data Source: STRINGDB
Publication Statistics
PubMed Score  20.13

PubMed score by year
PubTator Score  28.74

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer