Tbio ABI2 Abl interactor 2

Protein Summary

Description

Regulator of actin cytoskeleton dynamics underlying cell motility and adhesion. Functions as a component of the WAVE complex, which activates actin nucleating machinery Arp2/3 to drive lamellipodia formation (PubMed:21107423). Acts as regulator and substrate of nonreceptor tyrosine kinases ABL1 and ABL2 involved in processes linked to cell growth and differentiation. Positively regulates ABL1-mediated phosphorylation of ENAH, which is required for proper polymerization of nucleated actin filaments at the leading edge (PubMed:7590236, PubMed:8649853, PubMed:10498863). Contributes to the regulation of actin assembly at the tips of neuron projections. In particular, controls dendritic spine morphogenesis and may promote dendritic spine specification toward large mushroom-type spines known as repositories of memory in the brain (By similarity). In hippocampal neurons, may mediate actin-dependent BDNF-NTRK2 early endocytic trafficking that triggers dendrite outgrowth (By similarity). Participates in ocular lens morphogenesis, likely by regulating lamellipodia-driven adherens junction formation at the epithelial cell-secondary lens fiber interface (By similarity). Also required for nascent adherens junction assembly in epithelial cells (PubMed:15572692).

Uniprot Accession IDs

• Q9NYB9
• B4DSN1
• Q13147
• Q13249
• Q13801
• Q9BV70

Gene Name

• ABI2

Ensembl ID

• ENST00000261017
• ENSP00000261017
• ENSG00000138443

Symbol

• ARGBPIA
• AIP1
• ABI-2
• ABI2B
• AIP-1
• AblBP3
• argBP1
• SSH3BP2
• argBPIA
• argBPIB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
kinase perturbation	0.91
molecular function	0.84
microRNA	0.8
virus perturbation	0.79

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 2

DTO Classes

Protein / Enzyme Modulator / G-protein Modulator / Abl Interactor 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 204   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.75   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0