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Tchem
TERF2IP
Telomeric repeat-binding factor 2-interacting protein 1

Protein Summary
Description
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000300086
  • ENSP00000300086
  • ENSG00000166848

Symbol
  • DRIP5
  • RAP1
  • RAP1
  • DRIP5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
disease perturbation
0.99
ligand (protein) perturbation
0.96
biological process
0.93
virus perturbation
0.9


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.97   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 458   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.97   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 458   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 11
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
1
1
57.5
smoking initiation
1
1
1
50.7
smoking behavior
1
1
1
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
1
57.5
smoking initiation
1
50.7
smoking behavior
1
11.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TERF2 interacting protein
VGNC:9115
454253
Macaque
TERF2 interacting protein
712149
Mouse
MGI:1929871
57321
Rat
RGD:1309684
307861
Dog
TERF2 interacting protein
VGNC:49734
479643
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TERF2 interacting protein
Macaque
TERF2 interacting protein
Mouse
Rat
Dog
TERF2 interacting protein
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9NYB0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Base Excision Repair (R-HSA-73884)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cell Cycle
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cell Cycle
Cellular Senescence
Cellular responses to external stimuli
Protein-Protein Interactions (113)
1 – 10 of 113
TADA2B
Tbio
Family: TF
Novelty: 0.06387677
p_int: 0.999972987
p_ni: 0.000027013
Score: 0.185
Data Source: BioPlex,STRINGDB
DCLRE1B
Tbio
Family: Enzyme
Novelty: 0.0598925
p_int: 0.999939665
p_ni: 0.000060335
Score: 0.903
Data Source: BioPlex,STRINGDB
ARL4D
Tbio
Family: Enzyme
Novelty: 0.13254344
p_int: 0.998572156
p_ni: 0.001427844
Score: 0.209
Data Source: BioPlex,STRINGDB
CCDC106
Tdark
Novelty: 0.7081207
p_int: 0.998545152
p_ni: 0.001454848
Score: 0.232
Data Source: BioPlex,STRINGDB
TINF2
Tbio
Novelty: 0.0064505
p_int: 0.998218405
p_ni: 0.001781595
Score: 0.993
Data Source: BioPlex,STRINGDB
POT1
Tbio
Novelty: 0.01042607
p_int: 0.996045709
p_ni: 0.003954291
Score: 0.995
Data Source: BioPlex,STRINGDB
ACD
Tbio
Novelty: 0.00517732
p_int: 0.993204989
p_ni: 0.006795011
Score: 0.992
Data Source: BioPlex,STRINGDB
XAGE1A
Tbio
Novelty: 0.04421526
p_int: 0.987849289
p_ni: 0.012150711
Data Source: BioPlex
FBL
Tbio
Family: Enzyme
Novelty: 0.00080634
p_int: 0.985165197
p_ni: 0.014834803
Data Source: BioPlex
ARL4C
Tbio
Family: Enzyme
Novelty: 0.04764628
p_int: 0.982053461
p_ni: 0.017946539
Score: 0.185
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  13.97

PubMed score by year
PubTator Score  44.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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