MTMR4
Myotubularin-related protein 4
Protein Summary
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
- ENST00000323456
- ENSP00000325285
- ENSG00000108389
- KIAA0647
- ZFYVE11
- ZFYVE11
- FYVE-DSP2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
transcription factor binding site profile | 0.94 | ||
disease perturbation | 0.93 | ||
transcription factor perturbation | 0.8 | ||
pathway | 0.78 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.04 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 169 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 13.04 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 169 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
AURKA
Family: Kinase
Novelty: 0.0010868
p_int: 0.999986106
p_ni: 0.000013891
p_wrong: 3e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
DNAJC10
Novelty: 0.02258366
p_int: 0.999968314
p_ni: 0.00003167
p_wrong: 1.6e-8
Data Source: BioPlex
CDO1
Family: Enzyme
Novelty: 0.01682989
p_int: 0.999747035
p_ni: 0.000252965
Score: 0.165
Data Source: BioPlex,STRINGDB
HOOK3
Novelty: 0.0553474
p_int: 0.999281638
p_ni: 0.000718346
p_wrong: 1.6e-8
Data Source: BioPlex
ZNF263
Family: TF
Novelty: 0.098799
p_int: 0.999246473
p_ni: 0.000735611
p_wrong: 0.000017916
Score: 0.163
Data Source: BioPlex,STRINGDB
ALOX5
Family: Enzyme
Novelty: 0.00062988
p_int: 0.998406533
p_ni: 0.001593281
p_wrong: 1.87e-7
Data Source: BioPlex
IL10
Novelty: 0.00004352
p_int: 0.995871046
p_ni: 0.002614978
p_wrong: 0.001513975
Data Source: BioPlex
ZNF408
Family: TF
Novelty: 0.10649477
p_int: 0.994966748
p_ni: 0.0050332
p_wrong: 5.2e-8
Data Source: BioPlex
ZNF414
Novelty: 1.29024829
p_int: 0.990832694
p_ni: 0.009167006
p_wrong: 3e-7
Data Source: BioPlex
Nearest Tclin Targets (5)
Upstream (3)
Downstream (2)
1 – 3 of 3
Pathways (15)
Reactome (11)
KEGG (4)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Downregulation of TGF-beta receptor signaling | ||||
Reactome | Metabolism | ||||
Reactome | Metabolism of lipids | ||||
Reactome | PI Metabolism | ||||
Reactome | Phospholipid metabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Downregulation of TGF-beta receptor signaling | ||||
Metabolism | ||||
Metabolism of lipids | ||||
PI Metabolism | ||||
Phospholipid metabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (6)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 1 | 0 | 1.3 | 72.6 | |||||
intelligence | 3 | 2 | 1 | 6.5 | 60.1 | ||||
2 | 1 | 0 | 1.2 | 57.3 | |||||
C-reactive protein measurement | 1 | 1 | 1 | 46.9 | |||||
cognitive function measurement | 2 | 2 | 2 | 45.6 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 72.6 | |||||
intelligence | 1 | 6.5 | 60.1 | ||||
0 | 1.2 | 57.3 | |||||
C-reactive protein measurement | 1 | 46.9 | |||||
cognitive function measurement | 2 | 45.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | myotubularin related protein 4 | VGNC:9465 | 455157 | |||||
Mouse | MGI:2180699 | 170749 | ||||||
Rat | RGD:1310306 | 287607 | ||||||
Dog | myotubularin related protein 4 | VGNC:43485 | 480570 | |||||
Horse | myotubularin related protein 4 | VGNC:20427 | 100070938 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | myotubularin related protein 4 | |||||
Mouse | ||||||
Rat | ||||||
Dog | myotubularin related protein 4 | |||||
Horse | myotubularin related protein 4 | |||||
Publication Statistics
PubMed Score 13.04
PubMed score by year
PubTator Score 4.25
PubTator score by year
Related Publications
Text Mined References (18)
GeneRif Annotations (9)
Items per page:
0 of 0
PMID | Year | Title |
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