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Tbio
MTMR4
Myotubularin-related protein 4

Protein Summary
Description
Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323456
  • ENSP00000325285
  • ENSG00000108389

Symbol
  • KIAA0647
  • ZFYVE11
  • ZFYVE11
  • FYVE-DSP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
transcription factor binding site profile
0.94
disease perturbation
0.93
transcription factor perturbation
0.8
pathway
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 169   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.04   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
1
1
58.6
cognitive function measurement
1
1
1
58.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
1
58.6
cognitive function measurement
1
58.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 4
VGNC:9465
455157
Mouse
MGI:2180699
170749
Rat
RGD:1310306
287607
Dog
myotubularin related protein 4
VGNC:43485
480570
Horse
myotubularin related protein 4
VGNC:20427
100070938
Species
Name
OMA
EggNOG
Inparanoid
Chimp
myotubularin related protein 4
Mouse
Rat
Dog
myotubularin related protein 4
Horse
myotubularin related protein 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NYA4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (15)
Downregulation of TGF-beta receptor signaling (R-HSA-2173788)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Downregulation of TGF-beta receptor signaling
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Name
Explore in Pharos
Explore in Source
Downregulation of TGF-beta receptor signaling
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (94)
1 – 10 of 94
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.999986106
p_ni: 0.000013891
p_wrong: 3e-9
Score: 0.205
Data Source: BioPlex,STRINGDB
DNAJC10
Tbio
Novelty: 0.02258366
p_int: 0.999968314
p_ni: 0.00003167
p_wrong: 1.6e-8
Data Source: BioPlex
ZNF669
Tdark
Family: TF
Novelty: 2.09725685
p_int: 0.999907088
p_ni: 0.000092912
Data Source: BioPlex
CDO1
Tbio
Family: Enzyme
Novelty: 0.01682989
p_int: 0.999747035
p_ni: 0.000252965
Score: 0.165
Data Source: BioPlex,STRINGDB
HOOK3
Tbio
Novelty: 0.0553474
p_int: 0.999281638
p_ni: 0.000718346
p_wrong: 1.6e-8
Data Source: BioPlex
ZNF263
Tbio
Family: TF
Novelty: 0.098799
p_int: 0.999246473
p_ni: 0.000735611
p_wrong: 0.000017916
Score: 0.163
Data Source: BioPlex,STRINGDB
ALOX5
Tclin
Family: Enzyme
Novelty: 0.00062988
p_int: 0.998406533
p_ni: 0.001593281
p_wrong: 1.87e-7
Data Source: BioPlex
IL10
Tbio
Novelty: 0.00004352
p_int: 0.995871046
p_ni: 0.002614978
p_wrong: 0.001513975
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.10649477
p_int: 0.994966748
p_ni: 0.0050332
p_wrong: 5.2e-8
Data Source: BioPlex
ZNF414
Tdark
Novelty: 1.29024829
p_int: 0.990832694
p_ni: 0.009167006
p_wrong: 3e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  13.04

PubMed score by year
PubTator Score  4.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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