Tbio MTMR4 Myotubularin-related protein 4

Protein Summary

Description

Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para-nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5-trisphosphate (PIP3).

Uniprot Accession IDs

• Q9NYA4
• D3DTZ6
• Q8IV27
• Q9Y4D5

Gene Name

• MTMR4

Ensembl ID

• ENST00000323456
• ENSP00000325285
• ENSG00000108389

Symbol

• KIAA0647
• ZFYVE11
• ZFYVE11
• FYVE-DSP2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.97
transcription factor binding site profile	0.94
disease perturbation	0.93
transcription factor perturbation	0.8
pathway	0.78

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Myotubularin-related Protein 4

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Myotubularin-related Protein 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 169   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.46   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 169   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0